부산대학교 도서관

BACKGROUND: Nocturnal desaturation in cystic fibrosis (CF) may have prognostic implications because a significant and maintained nocturnal desaturation can contribute to the development and progression of pulmonary hypertension with cor pulmonale. Its relation with the desaturation in exercise has not been sufficiently studied. We aimed to determine whether desaturation during 6MWT can be an indicator of nocturnal desaturation in adult subjects with CF. METHODS: 57 subjects were included: 50.9% male, 27.5 [+ or -] 7.7 y old, mean FE[V.sub.1] = 2.37 [+ or -] 0.74 L, and %FE[V.sub.1] 67 [+ or -] 18.1%. Desaturation during 6MWT was defined as oxygen saturation ([mathematical expression not reproducible in ascii]) [less than or equal to] 90% or a decline of > 4 points in [mathematical expression not reproducible in ascii] from baseline, and nocturnal desaturation as a desaturation index > 4 or > 5% of sleep time with [mathematical expression not reproducible in ascii] < 90%. RESULTS: Desaturation observed during 6MWT in adult subjects with CF did not correlate with nocturnal desaturation (P = .27). Subjects with %FE[V.sub.1] [less than or equal to] 55% and diffusion capacity of carbon monoxide ([D.sub.LCO]) < 50 mmol/min/mm Hg were at higher risk of 6MWT desaturation. Nocturnal desaturation was more frequent in males, with [mathematical expression not reproducible in ascii] < 71 mm Hg in blood gas analysis. CONCLUSIONS: Desaturation observed in 6MWT cannot predict desaturation at night in adults with CF. Other parameters were identified as predictors of desaturation. Key words: saturation; walk; pulse oximetry; sleep; oxygen; exercise; hypoxemia. [Respir Care 2019;64(1):48-54. [c] 2019 Daedalus Enterprises]
IntroductionCystic fibrosis (CF) is one of the most common genetic diseases in whites, (1,2) with an incidence of about 1 in 5,000 live births in Spain. (2) It is an [...]