학술논문
Roles of hepatocyte growth factor scatter factor and the met receptor in the early development of the metanephros
Document Type
Academic Journal
Author
Source
The Journal of Cell Biology. Jan, 1995, Vol. 128 Issue 1-2, p171, 14 p.
Subject
Language
ISSN
0021-9525
Abstract
Experimental analysis of the roles of hepatocyte growth factor scatter factor (HGF SF) and met receptor in metanephric kidney development reveals that met and (HGF SF) genes colocalize in the mesenchymal cells during the early embryonic stages. Both met and HGF SF have an autocrine or paracrine role in the growth and survival of the mesenchymal cells and in the transition from mesenchyme to epithelium during nephrogenesis. Anti-HGF SF antibodies block mesenchymal cell differentiation, elevate cell death and disrupt ureteric bud morphogenesis.