학술논문
Plasma cytokines during acute human fascioliasis
Immunology and Host-Parasite Interactions - Short Communication
Immunology and Host-Parasite Interactions - Short Communication
Document Type
Academic Journal
Source
Parasitology Research. August 2021, Vol. 120 Issue 8, p2965, 4 p.
Subject
Language
English
ISSN
0932-0113
Abstract
Author(s): Catalina Aron-Said [sup.1], Martin Montes [sup.1] [sup.2], A. Clinton Jr White [sup.1] [sup.2], Miguel M. Cabada [sup.1] [sup.2] Author Affiliations: (1) grid.11100.31, 0000 0001 0673 9488, Instituto de Medicina [...]
Fascioliasis is a foodborne trematode endemic worldwide. Children under 15 years have the highest prevalence of infection. We hypothesized that acute fascioliasis would be associated with more pronounced cytokine changes than in chronic disease or no helminth infections. To test this hypothesis, 33 children who lived in the Peruvian highlands were classified into 3 groups: acute fascioliasis, chronic fascioliasis, and no helminth infection. Type Th1, Th2, and Th17 cytokines were measured in plasma by cytometric bead array. Children with acute infection had higher levels of IL-5 and IL-17 compared with controls (p < 0.001 and p < 0.007, respectively). The increased IL-5 plasma concentration in children with acute infection was associated with the eosinophilia found in that group.
Fascioliasis is a foodborne trematode endemic worldwide. Children under 15 years have the highest prevalence of infection. We hypothesized that acute fascioliasis would be associated with more pronounced cytokine changes than in chronic disease or no helminth infections. To test this hypothesis, 33 children who lived in the Peruvian highlands were classified into 3 groups: acute fascioliasis, chronic fascioliasis, and no helminth infection. Type Th1, Th2, and Th17 cytokines were measured in plasma by cytometric bead array. Children with acute infection had higher levels of IL-5 and IL-17 compared with controls (p < 0.001 and p < 0.007, respectively). The increased IL-5 plasma concentration in children with acute infection was associated with the eosinophilia found in that group.