부산대학교 도서관

Background: There are conflicting reports of the interaction between COVID-19 and HIV infection among coinfected individuals, and there is a particular dearth of evidence among populations in the Middle East. Aim: To determine if living with HIV and use of antiretroviral therapy increases susceptibility to, and severity of, COVID-19. Methods: This cross-sectional study was based on telephone survey of COVID-19 symptoms duration and clinical course among 200 people living with HIV (PLWHs) and a review of medical records in Beirut, Lebanon, during Spring 2021. Data were collected from consenting patients using standardized forms. The laboratory and medical characteristics of PLWHs with and without COVID-19 were compared and the outcomes of COVID-19 were described. A binary logistic regression model for contracting COVID-19 was constructed based on clinically relevant covariates consistently associated with COVID-19. Significance level was set at 0.05 and statistical analysis was performed using SPSS version 27.0. The Lebanese American University Institutional Review Board approved the study protocol. Results: Fifty-two of 200 PLWHs contracted COVID-19 but only 4 progressed to severe COVID-19. No significant differences were found with respect to gender, time since HIV diagnosis, most recent CD4 count, viral load, substance use, comorbidities, or use of antiretroviral therapy. Older PLWHs were at lower risk of contracting COVID-19; COVID-19 infection was significantly associated with younger age. Conclusions: COVID-19 infection was associated with younger age among PLWHs in Lebanon, possibly due to behavioural and socioeconomic factors. Keywords: COVID-19, HIV infection, antiretroviral agents, antiretroviral therapy, people living with HIV, COVID-19/HIV coinfection, Lebanon Contexte : Des informations contradictoires ont ete rapportees concernant l'interaction entre la COVID-19 et l'infection a VIH chez les personnes co-infectees, et les donnees probantes sont particulierement manquantes parmi les populations du Moyen-Orient. Objectif : Determiner si le fait de vivre avec le VIH et de suivre un traitement antiretroviral augmente la sensibilite a la COVID-19 et sa gravite. Methodes : La presente etude transversale est basee sur une enquete telephonique concernant la duree et l'evolution clinique des symptomes de COVID-19 aupres de 200 personnes vivant avec le VIH ainsi que sur une revue des dossiers medicaux a Beyrouth (Liban) au cours du printemps 2021. Les donnees ont ete recueillies aupres de patients consentants a l'aide de formulaires standardises. Les caracteristiques medicales et biologiques des personnes vivant avec le VIH et atteintes ou non de COVID-19 ont ete comparees et ses consequences ont ete decrites. Un modele de regression logistique binaire pour la COVID-19 a ete elabore a partir de covariables cliniquement pertinentes qui lui sont systematiquement associees. Le niveau de signification a ete fixe a 0,05 et l'analyse statistique a ete realisee a l'aide du logiciel SPSS version 27.0. Le Comite d'examen institutionnel de l'Universite libano-americaine a approuve le protocole de l'etude. Resultats : Cinquante-deux personnes vivant avec le VIH sur 200 ont contracte la COVID-19, mais seulement quatre en ont developpe une forme grave. Aucune difference significative n'a ete observee pour ce qui concerne le sexe, le temps ecoule depuis le diagnostic du VIH, le nombre le plus recent de CD4, la charge virale, l'utilisation de substances psychoactives, les comorbidites ou le suivi d'un traitement antiretroviral. Les personnes plus agees vivant avec le VIH etaient moins exposees au risque de contracter la COVID-19. Le risque lie a ce type d'infection etait fortement lie a un jeune age. Conclusion : L'infection COVID-19 etait associee a un age plus jeune chez les personnes vivant avec le VIH au Liban, probablement en raison de facteurs comportementaux et socioeconomiques.
Introduction The COVID-19 pandemic still poses a considerable threat to the lives of billions of people, despite vaccination efforts (1). Patient groups with specific comorbidities are suggested to be at [...]