학술논문
Antibody response, associated symptoms and profile of patients presumably infected by SARS-CoV-2 with taste or smell disorders in the SAPRIS multicohort study
santé, perception, pratiques relations et inégalités sociales en population générale pendant la crise COVID-19
santé, perception, pratiques relations et inégalités sociales en population générale pendant la crise COVID-19
Document Type
Report
Author
Ramillon, Julien; de Lamballerie, Xavier; Robineau, Olivier; Blanché, Hélène; Severi, Gianluca; Touvier, Mathilde; Zins, Marie; Carrat, Fabrice; Ancel, Pierre-Yves; Charles, Marie-Aline; Kab, Sofiane; Renuy, Adeline; Le-Got, Stéphane; Ribet, Céline; Wiernik, Emmanuel; Goldberg, Marcel; Artaud, Fanny; Gerbouin-Rérolle, Pascale; Enguix, Melody; Laplanche, Camille; Gomes-Rima, Roselyn; Hoang, Lyan; Correia, Emmanuelle; Barry, Alpha Amadou; Senina, Nadège; Szabo de Edelenyi, Fabien; Druesne-Pecollo, Nathalie; Esseddik, Younes; Hercberg, Serge; Benhammou, Valérie; Ritmi, Anass; Marchand, Laetitia; Zaros, Cécile; Lordmi, Elodie; Candea, Adriana; de Visme, Sophie; Simeon, Thierry; Thierry, Xavier; Geay, Bertrand; Dufourg, Marie-Noëlle; Milcent, Karen; Lusivika-Nzinga, Clovis; Pannetier, Gregory; Lapidus, Nathanael; Goderel, Isabelle; Dorival, Céline; Nicol, Jérôme; Lai, Cindy; Esperou, Hélène; Couffin-Cadiergues, Sandrine; Gagliolo, Jean-Marie; Sebaoun, Jean-Marc; Beaudoin, Jean-Christophe; Gressin, Laetitia; Morel, Valérie; Ouili, Ouissam; Deleuze, Jean-Francois; Priet, Stephane; Saba Villarroel, Paola Mariela; Fourié, Toscane; Mohamed Ali, Souand; Amroun, Abdenour; Seston, Morgan; Ayhan, Nazli; Pastorino, Boris
Source
BMC Infectious Diseases. April 14, 2023, Vol. 23 Issue 1
Subject
Language
English
ISSN
1471-2334
Abstract
Author(s): Julien Ramillon[sup.1] , Xavier de Lamballerie[sup.2] , Olivier Robineau[sup.3,4] , Hélène Blanché[sup.5] , Gianluca Severi[sup.6,7] , Mathilde Touvier[sup.8] , Marie Zins[sup.9] , Fabrice Carrat[sup.1,3] , Pierre-Yves Ancel[sup.] , Marie-Aline [...]
Background Taste or smell disorders have been reported as strongly associated with COVID-19 diagnosis. We aimed to identify subject characteristics, symptom associations, and antibody response intensity associated with taste or smell disorders. Methods We used data from SAPRIS, a study based on a consortium of five prospective cohorts gathering 279,478 participants in the French general population. In the analysis, we selected participants who were presumably infected by SARS-CoV-2 during the first epidemic wave. Results The analysis included 3,439 patients with a positive ELISA-Spike. Sex (OR = 1.28 [95% CI 1.05-1.58] for women), smoking (OR = 1.54 [95% CI 1.13-2.07]), consumption of more than 2 drinks of alcohol a day (OR = 1.37 [95% CI 1.06-1.76]) were associated with a higher probability of taste or smell disorders. The relationship between age and taste or smell disorders was non-linear. Serological titers were associated with taste or smell disorders: OR = 1.31 [95% CI 1.26-1.36], OR = 1.37 [95% CI 1.33-1.42] and OR = 1.34 [95% CI 1.29-1.39] for ELISA-Spike, ELISA-Nucleocapsid and seroneutralization, respectively. Among participants with taste or smell disorders, 90% reported a wide variety of other symptoms whereas 10% reported no other symptom or only rhinorrhea. Conclusions Among patients with a positive ELISA-Spike test, women, smokers and people drinking more than 2 drinks a day were more likely to develop taste or smell disorders. This symptom was strongly associated with an antibody response. The overwhelming majority of patients with taste or smell disorders experienced a wide variety of symptoms. Keywords: SARS-CoV-2, COVID-19 serological testing, Smell disorders, Taste disorders, General population
Background Taste or smell disorders have been reported as strongly associated with COVID-19 diagnosis. We aimed to identify subject characteristics, symptom associations, and antibody response intensity associated with taste or smell disorders. Methods We used data from SAPRIS, a study based on a consortium of five prospective cohorts gathering 279,478 participants in the French general population. In the analysis, we selected participants who were presumably infected by SARS-CoV-2 during the first epidemic wave. Results The analysis included 3,439 patients with a positive ELISA-Spike. Sex (OR = 1.28 [95% CI 1.05-1.58] for women), smoking (OR = 1.54 [95% CI 1.13-2.07]), consumption of more than 2 drinks of alcohol a day (OR = 1.37 [95% CI 1.06-1.76]) were associated with a higher probability of taste or smell disorders. The relationship between age and taste or smell disorders was non-linear. Serological titers were associated with taste or smell disorders: OR = 1.31 [95% CI 1.26-1.36], OR = 1.37 [95% CI 1.33-1.42] and OR = 1.34 [95% CI 1.29-1.39] for ELISA-Spike, ELISA-Nucleocapsid and seroneutralization, respectively. Among participants with taste or smell disorders, 90% reported a wide variety of other symptoms whereas 10% reported no other symptom or only rhinorrhea. Conclusions Among patients with a positive ELISA-Spike test, women, smokers and people drinking more than 2 drinks a day were more likely to develop taste or smell disorders. This symptom was strongly associated with an antibody response. The overwhelming majority of patients with taste or smell disorders experienced a wide variety of symptoms. Keywords: SARS-CoV-2, COVID-19 serological testing, Smell disorders, Taste disorders, General population