부산대학교 도서관

Byline: D. Bollens (1), M. Guiguet (3), P. Tangre (1), L. Rollinat (1), A. Rachline (1), J. L. Meynard (1), P. M. Girard (1), P. Benlian (2), M. C. Meyohas (1) Abstract: Abstract. Background: Our aim was to identify factors predisposing HIV-infected patients on long-term antiretroviral therapy (ART) to major hypertriglyceridemia (HTG). Patients and Methods: We conducted a retrospective, casecontrol study involving 76 HIV-infected patients with HTG, defined by 12-hour fasting plasma triglyceride (TG) > 4.5 mmol/l on at least one occasion, and 150 HIV-infected matched control patients with TG consistently below 1.8 mmol/l. Results: Patients coinfected by the hepatitis C virus appeared to be protected from HTG. In addition to known predisposing factors for HTG in HIV-infected patients (ART and immune/viral status), patients with a history of excess body weight were twice as likely to have HTG (odds ratio [OR] 2.8, 95% confidence interval [CI]: 1.1--6.9); HTG was also more frequent in patients who had a first-degree relative with cardiovascular disease (CVD) or a major risk factor for CVD (OR = 3.6, CI: 1.3--9.9). Conclusion: By identifying subgroups of highly predisposed patients, appropriate lifestyle and dietary measures could be recommended on ART initiation. Author Affiliation: (1) Infectious Diseases Unit, Saint Antoine Hospital, 184 rue du Faubourg, Saint-Antoine, 75571, Paris Cedex 12, France (2) Dept. of Biochemistry, Saint Antoine Hospital, Inserm U538, Paris, France (3) Inserm U444, Paris, France Article History: Registration Date: 01/01/2004 Received Date: 12/09/2003 Accepted Date: 12/02/2004