부산대학교 도서관

It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8[sup.+] T cell response to HIV-infected CD4[sup.+] T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8[sup.+] T cells were present in nonprogressors and progressors, only those of nonprogressors maintained a high proliferative capacity. This proliferation was coupled to increases in perforin expression. These results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8[sup.+] T cells linked to enhanced effector function. In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control.
Author(s): Stephen A. Migueles [1]; Alisha C. Laborico [1]; W. Lesley Shupert [1]; M. Shirin Sabbaghian [1]; Ronald Rabin [2]; Claire W. Hallahan [1]; Debbie Van Baarle [3]; Stefan Kostense [...]