학술논문
Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France
MAJOR ARTICLE
MAJOR ARTICLE
Document Type
Clinical report
Author
Source
Open Forum Infectious Diseases. July 2023, Vol. 10 Issue 7
Subject
Language
English
ISSN
2328-8957
Abstract
After its emergence in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), led to a global pandemic with far-reaching consequences for human health and medical [...]
Background. The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed. Methods. In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay. Results. The rate of waning of anti-HCoV spike immunoglobulin G antibodies was estimated as 0.22-0.47 [year.sup.-1] for children, and 0.13-0.27 [year.sup.-1] for adults. Seroreversion was estimated as 0.31-1.37 [year.sup.-1] in children and 0.19-0.72 [year.sup.-1] in adults. The estimated seroconversion rate in children was consistent with 20%-39% of children being infected every year with each HCoV. Conclusions. The high force of infection in children indicates that HCoVs may be responsible for a substantial proportion of fever episodes experienced by children. Keywords. epidemiology; seasonal human coronavirus; serocatalytic model; serology.
Background. The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed. Methods. In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay. Results. The rate of waning of anti-HCoV spike immunoglobulin G antibodies was estimated as 0.22-0.47 [year.sup.-1] for children, and 0.13-0.27 [year.sup.-1] for adults. Seroreversion was estimated as 0.31-1.37 [year.sup.-1] in children and 0.19-0.72 [year.sup.-1] in adults. The estimated seroconversion rate in children was consistent with 20%-39% of children being infected every year with each HCoV. Conclusions. The high force of infection in children indicates that HCoVs may be responsible for a substantial proportion of fever episodes experienced by children. Keywords. epidemiology; seasonal human coronavirus; serocatalytic model; serology.