학술논문
Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis
Document Type
Report
Author
Razazi, Keyvan; Luyt, Charles-Edouard; Voiriot, Guillaume; Rouzé, Anahita; Garnier, Marc; Ferré, Alexis; Camous, Laurent; Heming, Nicholas; Lapidus, Nathanaël; Charles-Nelson, Anais; Mekontso-Dessap, Armand; Mercat, Alain; Asfar, Pierre; Beloncle, François; Demiselle, Julien; Pham, Tài; Pavot, Arthur; Monnet, Xavier; Richard, Christian; Demoule, Alexandre; Dres, Martin; Mayaux, Julien; Beurton, Alexandra; Daubin, Cédric; Descamps, Richard; Joret, Aurélie; Du Cheyron, Damien; Pene, Frédéric; Chiche, Jean-Daniel; Jozwiak, Mathieu; Jaubert, Paul; Fartoukh, Muriel; Teulier, Marion; Blayau, Clarisse; L'Her, Erwen; Aubron, Cécile; Bodenes, Laetitia; Ferriere, Nicolas; Auchabie, Johann; Le Meur, Anthony; Pignal, Sylvain; Mazzoni, Thierry; Quenot, Jean-Pierre; Andreu, Pascal; Roudau, Jean-Baptiste; Labruyère, Marie; Nseir, Saad; Preau, Sébastien; Poissy, Julien; Mathieu, Daniel; Benhamida, Sarah; Paulet, Rémi; Roucaud, Nicolas; Thyrault, Martial; Daviet, Florence; Hraiech, Sami; Parzy, Gabriel; Sylvestre, Aude; Jochmans, Sébastien; Bouilland, Anne-Laure; Monchi, Mehran; Danguy des Déserts, Marc; Mathais, Quentin; Rager, Gwendoline; Pasquier, Pierre; Reignier, Jean; Seguin, Amélie; Garret, Charlotte; Canet, Emmanuel; Dellamonica, Jean; Saccheri, Clément; Lombardi, Romain; Kouchit, Yanis; Jacquier, Sophie; Mathonnet, Armelle; Nay, Mai-Ahn; Runge, Isabelle; Martino, Frédéric; Flurin, Laure; Rolle, Amélie; Carles, Michel; Coudroy, Rémi; Thille, Arnaud W.; Frat, Jean-Pierre; Rodriguez, Maeva; Beuret, Pascal; Tientcheu, Audrey; Vincent, Arthur; Michelin, Florian; Tamion, Fabienne; Carpentier, Dorothée; Boyer, Déborah; Girault, Christophe; Gissot, Valérie; Ehrmann, Stéphan; Salmon Gandonniere, Charlotte; Elaroussi, Djlali; Delbove, Agathe; Fedun, Yannick; Huntzinger, Julien; Lebas, Eddy; Kisoka, Grâce; Grégoire, Céline; Marchetta, Stella; Lambermont, Bernard; Argaud, Laurent; Baudry, Thomas; Bertrand, Pierre-Jean; Dargent, Auguste; Guitton, Christophe; Chudeau, Nicolas; Landais, Mickaël; Darreau, Cédric; Gros, Antoine; Lacave, Guillaume; Bruneel, Fabrice; Neuville, Mathilde; Devaquet, Jérôme; Tachon, Guillaume; Gallot, Richard; Chelha, Riad; Galbois, Arnaud; Jallot, Anne; Chalumeau Lemoine, Ludivine; Kuteifan, Khaldoun; Pointurier, Valentin; Jandeaux, Louise-Marie; Mootien, Joy; Damoisel, Charles; Sztrymf, Benjamin; Schmidt, Matthieu; Combes, Alain; Chommeloux, Juliette; Luyt, Charles Edouard; Schortgen, Frédérique; Rusel, Leon; Jung, Camille; Gobert, Florent; Vimpere, Damien; Lamhaut, Lionel; Sauneuf, Bertrand; Charrrier, Liliane; Calus, Julien; Desmeules, Isabelle; Painvin, Benoît; Tadie, Jean-Marc; Castelain, Vincent; Michard, Baptiste; Herbrecht, Jean-Etienne; Baldacini, Mathieu; Weiss, Nicolas; Demeret, Sophie; Marois, Clémence; Rohaut, Benjamin; Moury, Pierre-Henri; Savida, Anne-Charlotte; Couadau, Emmanuel; Série, Mathieu; Alexandru, Nica; Bruel, Cédric; Fontaine, Candice; Garrigou, Sonia; Courtiade Mahler, Juliette; Leclerc, Maxime; Ramakers, Michel; Garçon, Pierre; Massou, Nicole; Van Vong, Ly; Sen, Juliane; Lucas, Nolwenn; Chemouni, Franck; Stoclin, Annabelle; Avenel, Alexandre; Faure, Henri; Gentilhomme, Angélie; Ricome, Sylvie; Abraham, Paul; Monard, Céline; Textoris, Julien; Rimmele, Thomas; Montini, Florent; Lejour, Gabriel; Lazard, Thierry; Etienney, Isabelle; Kerroumi, Younes; Dupuis, Claire; Bereiziat, Marine; Coupez, Elisabeth; Thouy, François; Hofmann, Clément; Donat, Nicolas; Chrisment, Anne; Blot, Rose-Marie; Kimmoun, Antoine; Jacquot, Audrey; Mattei, Matthieu; Levy, Bruno; Ravan, Ramin; Dopeux, Loïc; Liteaudon, Jean-Mathias; Roux, Delphine; Rey, Brice; Anghel, Radu; Schenesse, Deborah; Gevrey, Vincent; Castanera, Jermy; Petua, Philippe; Madeux, Benjamin; Hartman, Otto; Piagnerelli, Michael; Joosten, Anne; Noel, Cinderella; Biston, Patrick; Noel, Thibaut; Bouar, Gurvan L. E.; Boukhanza, Messabi; Demarest, Elsa; Bajolet, Marie-France; Charrier, Nathanaël; Quenet, Audrey; Zylberfajn, Cécile; Dufour, Nicolas; Mégarbane, Bruno; Voicu, Sébastian; Deye, Nicolas; Malissin, Isabelle; Legay, François; Debarre, Matthieu; Barbarot, Nicolas; Fillatre, Pierre; Delord, Bertrand; Laterrade, Thomas; Saghi, Tahar; Pujol, Wilfried; Cungi, Pierre Julien; Esnault, Pierre; Cardinale, Mickael; Hong Tuan Ha, Vivien; Fleury, Grégory; Brou, Marie-Ange; Zafmahazo, Daniel; Tran-Van, David; Avargues, Patrick; Carenco, Lisa; Robin, Nicolas; Ouali, Alexandre; Houdou, Lucie; Le Terrier, Christophe; Suh, Noémie; Primmaz, Steve; Pugin, Jérome; Weiss, Emmanuel; Gauss, Tobias; Moyer, Jean-Denis; Burtz, Catherine Paugam; La Combe, Béatrice; Smonig, Rolland; Violleau, Jade; Cailliez, Pauline; Chelly, Jonathan; Marchalot, Antoine; Saladin, Cécile; Bigot, Christelle; Fayolle, Pierre-Marie; Fatséas, Jules; Ibrahim, Amr; Resiere, Dabor; Hage, Rabih; Cholet, Clémentine; Cantier, Marie; Trouiler, Pierre; Montravers, Philippe; Lortat-Jacob, Brice; Tanaka, Sebastien; Tran Dinh, Alexy; Duranteau, Jacques; Harrois, Anatole; Dubreuil, Guillaume; Werner, Marie; Godier, Anne; Hamada, Sophie; Zlotnik, Diane; Nougue, Hélène; Carteaux, Guillaume; de Prost, Nicolas; Mongardon, Nicolas; Lamraoui, Meriam; Alessandri, Claire; de Roux, Quentin; de Roquetaillade, Charles; Chousterman, Benjamin G.; Mebazaa, Alexandre; Gayat, Etienne; Pardo, Emmanuel; Satre-Buisson, Lea; Gutton, Christophe; Yvin, Elise; Marcault, Clémence; Azoulay, Elie; Darmon, Michael; Ait Oufella, Hafid; Hariri, Geofroy; Urbina, Tomas; Mazerand, Sandie; Santi, Francesca; Moine, Pierre; Annane, Djillali; Bouglé, Adrien; Omar, Edris; Lancelot, Aymeric; Begot, Emmanuelle; Plantefeve, Gaétan; Contou, Damien; Mentec, Hervé; Pajot, Olivier; Faguer, Stanislas; Cointault, Olivier; Lavayssiere, Laurence; Nogier, Marie-Béatrice; Jamme, Matthieu; Pichereau, Claire; Hayon, Jan; Outin, Hervé; Dépret, François; Coutrot, Maxime; Chaussard, Maité; Guillemet, Lucie; Gofn, Pierre; Thouny, Romain; Guntz, Julien; Jadot, Laurent; Persichini, Romain; Jean-Michel, Vanessa; Georges, Hugues; Caulier, Thomas; Pradel, Gaël; Hausermann, Marie-Hélène; Nguyen-Valat, Thi My Hue; Boudinaud, Michel; Vivier, Emmanuel; Rosseli, Sylvène; Bourdin, Gaël; Pommier, Christian; Vinclair, Marc; Poignant, Simon; Mons, Sandrine; Bougouin, Wulfran; Bruna, Franklin; Maestraggi, Quentin; Roth, Christian; Bitker, Laurent; Dhelft, François; Bonnet-Chateau, Justine; Filippelli, Mathilde; Morichau-Beauchant, Tristan; Thierry, Stéphane; Le Roy, Charlotte; Jouan, Mélanie Saint; Goncalves, Bruno; Mazeraud, Aurélien; Daniel, Matthieu; Sharshar, Tarek; Cadoz, Cyril; Gaci, Rostane; Gette, Sébastien; Louis, Guillaune; Sacleux, Sophie-Caroline; Ordan, Marie-Amélie; Cravoisy, Aurélie; Conrad, Marie; Courte, Guilhem; Gibot, Sébastien; Benzidi, Younès; Casella, Claudia; Serpin, Laurent; Setti, Jean-Lou; Besse, Marie-Catherine; Bourreau, Anna; Pillot, Jérôme; Rivera, Caroline; Vinclair, Camille; Robaux, Marie-Aline; Achino, Chloé; Delignette, Marie-Charlotte; Mazard, Tessa; Aubrun, Frédéric; Bouchet, Bruno; Frérou, Aurélien; Muller, Laura; Quentin, Charlotte; Degoul, Samuel; Stihle, Xavier; Sumian, Claude; Bergero, Nicoletta; Lanaspre, Bernard; Quintard, Hervé; Maiziere, Eve Marie; Egreteau, Pierre-Yves; Leloup, Guillaume; Berteau, Florin; Cottrel, Marjolaine; Bouteloup, Marie; Jeannot, Matthieu; Blanc, Quentin; Saison, Julien; Geneau, Isabelle; Grenot, Romaric; Ouchike, Abdel; Hazera, Pascal; Masse, Anne-Lyse; Demiri, Suela; Vezinet, Corinne; Baron, Elodie; Benchetrit, Deborah; Monsel, Antoine; Trebbia, Grégoire; Schaack, Emmanuelle; Lepecq, Raphaël; Bobet, Mathieu; Vinsonneau, Christophe; Dekeyser, Thibault; Delforge, Quentin; Rahmani, Imen; Vivet, Bérengère; Paillot, Jonathan; Hierle, Lucie; Chaignat, Claire; Valette, Sarah; Her, Benoït; Brunet, Jennifer; Page, Mathieu; Boiste, Fabienne; Collin, Anthony; Bavozet, Florent; Garin, Aude; Dlala, Mohamed; Mhamdi, Kais; Beilouny, Bassem; Lavalard, Alexandra; Perez, Severine; Veber, Benoit; Guitard, Pierre-Gildas; Gouin, Philippe; Lamacz, Anna; Plouvier, Fabienne; Delaborde, Bertrand P.; Kherchache, Aïssa; Chaalal, Amina; Ricard, Jean-Damien; Amouretti, Marc; Freita-Ramos, Santiago; Roux, Damien; Constantin, Jean-Michel; Assef, Mona; Lecore, Marine; Selves, Agathe; Prevost, Florian; Lamer, Christian; Shi, Ruiying; Knani, Lyes; Floury, Sébastien Pili; Vettoretti, Lucie; Levy, Michael; Marsac, Lucile; Dauger, Stéphane; Guilmin-Crépon, Sophie; Winiszewski, Hadrien; Piton, Gael; Soumagne, Thibaud; Capellier, Gilles; Putegnat, Jean-Baptiste; Bayle, Frédérique; Perrou, Maya; Thao, Ghyslaine; Géri, Guillaume; Charron, Cyril; Repessé, Xavier; Vieillard-Baron, Antoine; Guilbart, Mathieu; Roger, Pierre-Alexandre; Hinard, Sébastien; Macq, Pierre-Yves; Chaulier, Kevin; Goutte, Sylvie; Chillet, Patrick; Pitta, Anaïs; Darjent, Barbara; Bruneau, Amandine; Lasocki, Sigismond; Leger, Maxime; Gergaud, Soizic; Lemarie, Pierre; Terzi, Nicolas; Schwebel, Carole; Dartevel, Anaïs; Galerneau, Louis-Marie; Diehl, Jean-Luc; Hauw-Berlemont, Caroline; Péron, Nicolas; Guérot, Emmanuel; Amoli, Abolfazl Mohebbi; Benhamou, Michel; Deyme, Jean-Pierre; Andremont, Olivier; Lena, Diane; Cady, Julien; Causeret, Arnaud; De La Chapelle, Arnaud; Cracco, Christophe; Rouleau, Stéphane; Schnell, David; Foucault, Camille; Lory, Cécile; Chapelle, Thibault; Bruckert, Vincent; Garcia, Julie; Sahraoui, Abdlazize; Abbosh, Nathalie; Bornstain, Caroline; Pernet, Pierre; Poirson, Florent; Pasem, Ahmed; Karoubi, Philippe; Poupinel, Virginie; Gauthier, Caroline; Bouniol, François; Feuchere, Philippe; Heron, Anne; Carreira, Serge; Emery, Malo; Le Floch, Anne Sophie; Giovannangeli, Luana; Herzog, Nicolas; Giacardi, Christophe; Baudic, Thibaut; Thill, Chloé; Lebbah, Said; Palmyre, Jessica; Tubach, Florence; Hajage, David; Bonnet, Nicolas; Ebstein, Nathan; Gaudry, Stéphane; Cohen, Yves; Noublanche, Julie; Lesieur, Olivier; Sément, Arnaud; Roca-Cerezo, Isabel; Pascal, Michel; Sma, Nesrine; Colin, Gwenhaël; Lacherade, Jean-Claude; Bionz, Gauthier; Maquigneau, Natacha; Bouzat, Pierre; Durand, Michel; Hérault, Marie-Christine; Payen, Jean-Francois
Source
Critical Care. April 20, 2024, Vol. 28 Issue 1
Subject
Language
English
ISSN
1364-8535
Abstract
Background Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly related to Enterobacterales. Data regarding extended-spectrum beta-lactamase producing Enterobacterales (ESBL-E) VAP are scarce. We aimed to investigate risk factors and outcomes of ESBL-E related VAP among critically ill coronavirus infectious disease-19 (COVID-19) patients who developed Enterobacterales related VAP. Patients and methods We performed an ancillary analysis of a multicenter prospective international cohort study (COVID-ICU) that included 4929 COVID-19 critically ill patients. For the present analysis, only patients with complete data regarding resistance status of the first episode of Enterobacterales related VAP (ESBL-E and/or carbapenem-resistant Enterobacterales, CRE) and outcome were included. Results We included 591 patients with Enterobacterales related VAP. The main causative species were Enterobacter sp (n = 224), E. coli (n = 111) and K. pneumoniae (n = 104). One hundred and fifteen patients (19%), developed a first ESBL-E related VAP, mostly related to Enterobacter sp (n = 40), K. pneumoniae (n = 36), and E. coli (n = 31). Eight patients (1%) developed CRE related VAP. In a multivariable analysis, African origin (North Africa or Sub-Saharan Africa) (OR 1.7 [1.07-2.71], p = 0.02), time between intubation and VAP (OR 1.06 [1.02-1.09], p = 0.002), PaO.sub.2/FiO.sub.2 ratio on the day of VAP (OR 0.997 [0.994-0.999], p = 0.04) and trimethoprim-sulfamethoxazole exposure (OR 3.77 [1.15-12.4], p = 0.03) were associated with ESBL-E related VAP. Weaning from mechanical ventilation and mortality did not significantly differ between ESBL-E and non ESBL-E VAP. Conclusion ESBL-related VAP in COVID-19 critically-ill patients was not infrequent. Several risk factors were identified, among which some are modifiable and deserve further investigation. There was no impact of resistance of the first Enterobacterales related episode of VAP on outcome. Keywords: COVID-19, ARDS, Nosocomial pneumonia, Ventilator-associated pneumonia, ESBL
Author(s): Keyvan Razazi[sup.1,15,2] , Charles-Edouard Luyt[sup.3] , Guillaume Voiriot[sup.4] , Anahita Rouzé[sup.5] , Marc Garnier[sup.6] , Alexis Ferré[sup.7] , Laurent Camous[sup.8] , Nicholas Heming[sup.10,11,9] , Nathanaël Lapidus[sup.12] , Anais Charles-Nelson[sup.13] [...]
Author(s): Keyvan Razazi[sup.1,15,2] , Charles-Edouard Luyt[sup.3] , Guillaume Voiriot[sup.4] , Anahita Rouzé[sup.5] , Marc Garnier[sup.6] , Alexis Ferré[sup.7] , Laurent Camous[sup.8] , Nicholas Heming[sup.10,11,9] , Nathanaël Lapidus[sup.12] , Anais Charles-Nelson[sup.13] [...]