학술논문
Does the preoperative fasting period affect the liver in a distant organ model of renal ischaemia reperfusion?
Original Article
Original Article
Document Type
Report
Author
Source
Saudi Medical Journal. February 2023, Vol. 44 Issue 2, p171, 7 p.
Subject
Language
English
ISSN
0379-5284
Abstract
Renal ischaemia reperfusion (IR) damage can occur for many reasons, but usually due to shock, sepsis, organ transplantation, and vascular surgery. (1) High mortality rates can be seen with this [...]
Objectives: To experimentally evaluate the effects of preoperative fasting duration on distant organ liver in renal ischaemia-reperfusion (IR) injury. Methods: This is an experimental study. In the study, 3 groups were formed. In Group A, abdominal laparotomy was carried out after 12 hours of preoperative fasting without any IR damage. In Group B, IR injury was carried out after 12 hours of preoperative fasting, and abdominal laparotomy was carried out, in Group C after 2 hours of fasting after IR injury. Apoptosis, congestion, balloon degeneration, nuclear pleomorphism, and leukocyte infiltration were examined histopathologically and tumor necrosis factor-alpha (TNF-[alpha]), interleukin (IL) -1 beta, IL-6, and IL-10 were evaluated biochemically. Results: A statistically significant difference was determined between the groups in respect of postoperative IL-10 levels (p=0.020) with significantly lower levels determined in Group C than in Groups A and B (p=0.021). Similar rates of mild nuclear polymorphism were seen with no statistically significant difference determined between the groups (p>0.167). A statistically significant difference was determined between the groups in respect of the congestion scores (p Conclusion: With this result, it would be correct to say that the short preoperative fasting period has protective effects on the liver tissue. Keywords: ERAS, ischaemia reperfusion, preoperative fasting [phrase omitted]
Objectives: To experimentally evaluate the effects of preoperative fasting duration on distant organ liver in renal ischaemia-reperfusion (IR) injury. Methods: This is an experimental study. In the study, 3 groups were formed. In Group A, abdominal laparotomy was carried out after 12 hours of preoperative fasting without any IR damage. In Group B, IR injury was carried out after 12 hours of preoperative fasting, and abdominal laparotomy was carried out, in Group C after 2 hours of fasting after IR injury. Apoptosis, congestion, balloon degeneration, nuclear pleomorphism, and leukocyte infiltration were examined histopathologically and tumor necrosis factor-alpha (TNF-[alpha]), interleukin (IL) -1 beta, IL-6, and IL-10 were evaluated biochemically. Results: A statistically significant difference was determined between the groups in respect of postoperative IL-10 levels (p=0.020) with significantly lower levels determined in Group C than in Groups A and B (p=0.021). Similar rates of mild nuclear polymorphism were seen with no statistically significant difference determined between the groups (p>0.167). A statistically significant difference was determined between the groups in respect of the congestion scores (p Conclusion: With this result, it would be correct to say that the short preoperative fasting period has protective effects on the liver tissue. Keywords: ERAS, ischaemia reperfusion, preoperative fasting [phrase omitted]