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To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1567-1364.2006.00121.x Byline: Mary Ann Jabra-Rizk (1,2), Mark Shirtliff (3,4), Cathy James (1,3), Timothy Meiller (1) Keywords: farnesol; fluconazole resistance; biofilm; Candida dubliniensis; Candida albicans Abstract: Abstract Candida dubliniensis and Candida albicans are dimorphic fungal species with a number of pathogenic capabilities, including biofilm formation, systemic infection and development of fluconazole resistance. In this study, the ability of farnesol to disrupt these virulence capabilities was investigated. Biofilm assessment and susceptibility studies indicated antifungal and antibiofilm properties for farnesol on both species with a disruptive effect on the cell membrane. Synergy testing of farnesol and fluconazole in resistant strains resulted in reversal of fluconazole resistance, indicating a potential application for farnesol as an adjuvant therapeutic agent. Author Affiliation: (1)Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, MD, USA (2)Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, USA (3)Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD, USA (4)Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD, USA Article History: Received 12 January 2006; revised 24 February 2006; accepted 13 April 2006.First published online 21 June 2006. Article note: Correspondence: Mary Ann Jabra-Rizk, Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, 666 W Baltimore Street, Room 4G03, Baltimore, MD 21201, USA. Tel.: +1 410 708 7628; fax: +1 410 706 0519; e-mail: mrizk@umaryland.edu