부산대학교 도서관

Study Objectives: Little is known about the interrelationships between sleep regularity, obstructive sleep apnea (OSA) and important health markers. This study examined whether irregular sleep is associated with OSA and hypertension, and if this modifies the known association between OSA and hypertension. Methods: Six hundred and two adults (age mean(SD) = 56.96(5.51) years, female = 60%) from the Raine Study who were not evening or night shift workers were assessed for OSA (in-laboratory polysomnography; apnea--hypopnea index [greater than or equal to] 15 events/hour), hypertension (doctor diagnosed, or systolic blood pressure [greater than or equal to]140 mmHg and/or diastolic [greater than or equal to]90 mmHg) and sleep (wrist actigraphy for [greater than or equal to]5 days). A sleep regularity index (SRI) was determined from actigraphy. Participants were categorized by tertiles as severely irregular, mildly irregular, or regular sleepers. Logistic regression models examined the interrelationships between SRI, OSA and hypertension. Covariates included age, sex, body mass index, actigraphy sleep duration, insomnia, depression, activity, alcohol, smoking, and antihypertensive medication. Results: Compared to regular sleepers, participants with mildly irregular (OR 1.97, 95% confidence intervals [CI] 1.20 to 3.27) and severely irregular (OR 2.06, 95% CI: 1.25 to 3.42) sleep had greater odds of OSA. Compared to those with no OSA and regular sleep, OSA and severely irregular sleep combined had the highest odds of hypertension (OR 2.34 95% CI: 1.07 to 5.12; p for interaction = 0.02) while those with OSA and regular/mildly irregular sleep were not at increased risk (p for interaction = 0.20). Conclusions: Sleep irregularity may be an important modifiable target for hypertension among those with OSA. Key words: sleep regularity; patterns; actigraphy; hypertension; obstructive sleep apnea
Introduction Obstructive sleep apnea (OSA) is a prevalent sleep-breathing disorder estimated to impact one billion middle-aged adults globally [1]. It is characterized by intermittent episodes of partial or complete upper [...]