부산대학교 도서관

Background: Within-patient tacrolimus level variability >30% has been shown to be a risk factor for de novo donor-specific antibody formation and death-censored graft failure among kidney transplant recipients. The burden of tacrolimus variability and the correlation between variability and subtherapeutic tacrolimus levels were examined in a large national data set. Methods: All tacrolimus levels drawn at LabCorp® facilities in the United States with a diagnosis code for kidney transplant between November 2011 and September 2017 were examined, excluding values that could represent new allografts. Tacrolimus variability was calculated if at least 3 levels were available. The percentage of subtherapeutic ( Keywords: Kidney transplantation, Tacrolimus variability, Subtherapeutic levels
Author(s): Pratik B. Shah (corresponding author) [a]; Jennifer L. Ennis [b]; Patrick N. Cunningham [a]; Michelle A. Josephson [a]; Rita L. McGill [a] Introduction Kidney transplantation increases both longevity and [...]