학술논문
Chemotherapy line-associated differences in quality of life in patients with advanced cancer
Document Type
Academic Journal
Author
Source
Supportive Care in Cancer. October 1, 2012, Vol. 20 Issue 10, p2399, 7 p.
Subject
Language
English
ISSN
0941-4355
Abstract
Introduction Health-related quality of life (QOL) of patients with cancer has been identified as an important end point in research and clinical practice [1]. Especially in patients with advanced disease [...]
Purpose The aim of this study was to investigate quality of life (QOL) differences between patients receiving first, second, or third-line palliative chemotherapy (CT). Furthermore, QOL was also compared to a sex- and age-matched sample of healthy controls. Methods Patients with different metastatic cancers receiving palliative CT were approached to complete the EORTC QLQ-C30 questionnaire by means of touch-screen computers before the start of CT, after 3 cycles and at the end of cytostatic treatment. Results One hundred four patients were recruited for QOL assessment (56.9% of patients in first, 22.5% second and 20.6% third- or above-line palliative CT). Compared to healthy controls, they suffered from substantial QOL impairments in all EORTC QLQ-C30 sub-domains. In regard to CT lines, patients with first-line CT reached better scores in emotional and social functioning than second-line patients and less financial difficulties than third-line patients. Despite the high level of impairment in the patient sample, electronic data collection proved to be feasible and well accepted. Conclusions The results indicate that patients receiving third-or above-line palliative CT are confronted with stronger QOL impairments than first- and second-line patients. Supported by its feasibility and acceptance of by patients, electronic QOL data capture is an attractive method to screen for symptoms and track their course within clinical routine. Keywords Palliative cancer patients * Patient-reported outcomes * Quality of life * Multiple chemotherapy lines
Purpose The aim of this study was to investigate quality of life (QOL) differences between patients receiving first, second, or third-line palliative chemotherapy (CT). Furthermore, QOL was also compared to a sex- and age-matched sample of healthy controls. Methods Patients with different metastatic cancers receiving palliative CT were approached to complete the EORTC QLQ-C30 questionnaire by means of touch-screen computers before the start of CT, after 3 cycles and at the end of cytostatic treatment. Results One hundred four patients were recruited for QOL assessment (56.9% of patients in first, 22.5% second and 20.6% third- or above-line palliative CT). Compared to healthy controls, they suffered from substantial QOL impairments in all EORTC QLQ-C30 sub-domains. In regard to CT lines, patients with first-line CT reached better scores in emotional and social functioning than second-line patients and less financial difficulties than third-line patients. Despite the high level of impairment in the patient sample, electronic data collection proved to be feasible and well accepted. Conclusions The results indicate that patients receiving third-or above-line palliative CT are confronted with stronger QOL impairments than first- and second-line patients. Supported by its feasibility and acceptance of by patients, electronic QOL data capture is an attractive method to screen for symptoms and track their course within clinical routine. Keywords Palliative cancer patients * Patient-reported outcomes * Quality of life * Multiple chemotherapy lines