학술논문
Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer
Document Type
Academic Journal
Author
Source
Biomedical Reports. November 2020, Vol. 13 Issue 5, p1J, 11 p.
Subject
Language
English
ISSN
2049-9434
Abstract
Introduction Colorectal cancer (CRC) is a common malignancy with high incidence and mortality rates both in male and female patients in Japan, although the overall 5-year survival rate is relatively [...]
NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the reformation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide polymorphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhibited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers ( Key words: NINEIN, centrosome, single nucleotide polymorphism, colon cancer, tumor susceptibility
NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the reformation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide polymorphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhibited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers ( Key words: NINEIN, centrosome, single nucleotide polymorphism, colon cancer, tumor susceptibility