학술논문
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
Document Type
Academic Journal
Author
Source
Cell. August 26, 2005, Vol. 122 Issue 4, p553, 11 p.
Subject
Language
English
ISSN
0092-8674
Abstract
Regulation by the let-7 microRNAs (miRNA) in Caenorhabditis elegans leads to degradation of its lin-41 target mRNA, despite the fact that its 3'unrelated regions (UTR) regulatory sequences can only partially base pair with the miRNA. The results reveal that mRNAs containing partial miRNA complementary sites can be targeted for degradation in vivo, raising the possibility that regulation at the level of mRNA stability may be common than previously appreciated for the miRNA pathway.