학술논문
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study
Document Type
Clinical report
Author
Eyre, David W; Lumley, Sheila F; O'Donnell, Denise; Campbell, Mark; Sims, Elizabeth; Lawson, Elaine; Warren, Fiona; James, Tim; Cox, Stuart; Howarth, Alison; Doherty, George; Hatch, Stephanie B; Kavanagh, James; Chau, Kevin K; Fowler, Philip W; Swann, Jeremy; Volk, Denis; Yang-Turner, Fan; Stoesser, Nicole; Matthews, Philippa C; Dudareva, Maria; Davies, Timothy; Shaw, Robert H; Peto, Leon; Downs, Louise O; Vogt, Alexander; Amini, Ali; Young, Bernadette C; Drennan, Philip George; Mentzer, Alexander J; Skelly, Donal T; Karpe, Fredrik; Neville, Matt J; Andersson, Monique; Brent, Andrew J; Jones, Nicola; Martins Ferreira, Lucas; Christott, Thomas; Marsden, Brian D; Hoosdally, Sarah; Cornall, Richard; Crook, Derrick W; Stuart, David I; Screaton, Gavin; Watson, Adam JR; Taylor, Adan; Chetwynd, Alan; Grassam-Rowe, Alexander; Mighiu, Alexandra S; Livingstone, Angus; Killen, Annabel; Rigler, Caitlin; Harries, Callum; East, Cameron; Lee, Charlotte; Mason, Chris JB; Holland, Christian; Thompson, Connor; Hennesey, Conor; Savva, Constantinos; Kim, David S; Harris, Edward WA; McGivern, Euan J; Qian, Evelyn; Rothwell, Evie; Back, Francesca; Kelly, Gabriella; Watson, Gareth; Howgego, Gregory; Chase, Hannah; Danbury, Hannah; Laurenson-Schafer, Hannah; Ward, Harry L; Hendron, Holly; Vorley, Imogen C; Tol, Isabel; Gunnell, James; Ward, Jocelyn LF; Drake, Jonathan; Wilson, Joseph D; Morton, Joshua; Dequaire, Julie; O'Byrne, Katherine; Motohashi, Kenzo; Harper, Kirsty; Ravi, Krupa; Millar, Lancelot J; Peck, Liam J; Oliver, Madeleine; English, Marcus Rex; Kumarendran, Mary; Wedlich, Matthew; Ambler, Olivia; Deal, Oscar T; Sweeney, Owen; Cowie, Philip; Naudé, Rebecca te Water; Young, Rebecca; Freer, Rosie; Scott, Samuel; Sussmes, Samuel; Peters, Sarah; Pattenden, Saxon; Waite, Seren; Johnson, Síle Ann; Kourdov, Stefan; Santos-Paulo, Stephanie; Dimitrov, Stoyan; Kerneis, Sven; Ahmed-Firani, Tariq; King, Thomas B; Ritter, Thomas G; Foord, Thomas H; De Toledo, Zoe; Christie, Thomas; Gergely, Bernadett; Axten, David; Simons, Emma-Jane; Nevard, Heather; Philips, Jane; Szczurkowska, Justyna; Patel, Kaisha; Smit, Kyla; Warren, Laura; Morgan, Lisa; Smith, Lucianne; Robles, Maria; McKnight, Mary; Luciw, Michael; Gates, Michelle; Sande, Nellia; Turford, Rachel; Ray, Roshni; Rughani, Sonam; Mitchell, Tracey; Bellinger, Trisha; Wharton, Vicki; Justice, Anita; Jesuthasan, Gerald; Wareing, Susan; Huda Mohamad Fadzillah, Nurul; Cann, Kathryn; Kirton, Richard; Sutton, Claire; Salvagno, Claudia; DAmato, Gabriella; Pill, Gemma; Butcher, Lisa; Rylance-Knight, Lydia; Tabirao, Merline; Moroney, Ruth; Wright, Sarah
Source
eLife. August 21, 2020, Vol. 9
Subject
Language
English
ISSN
2050-084X
Abstract
We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45--6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99--3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07--2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28--0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25--2.21]) and Asian (1.51 [1.28--1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34--3.15]).
Byline: David W Eyre, Sheila F Lumley, Denise O'Donnell, Mark Campbell, Elizabeth Sims, Elaine Lawson, Fiona Warren, Tim James, Stuart Cox, Alison Howarth, George Doherty, Stephanie B Hatch, James Kavanagh, [...]
Byline: David W Eyre, Sheila F Lumley, Denise O'Donnell, Mark Campbell, Elizabeth Sims, Elaine Lawson, Fiona Warren, Tim James, Stuart Cox, Alison Howarth, George Doherty, Stephanie B Hatch, James Kavanagh, [...]