학술논문
In extremis diagnosis of celiac disease and concomitant wheat allergy
CASE REPORT
CASE REPORT
Document Type
Clinical report
Author
Source
The Turkish Journal of Gastroenterology. July 2018, Vol. 29 Issue 4, p515, 3 p.
Subject
Language
English
ISSN
1300-4948
Abstract
INTRODUCTION Celiac disease (CD) and concomitant immunoglobulin E (IgE)-mediated wheat allergy are not commonly described in the literature, and even the possible coexistence of T helper 1 (Th1)- and Th2-type [...]
Celiac disease (CD) and concomitant wheat allergy are not commonly described in the literature. Both can have almost the same treatment consisting of a gluten-free or wheat-free diet. On the other hand, they are based on totally different pathogenetic mechanisms and can be easily underdiagnosed, particularly CD. We describe a peculiar case of a young female patient affected by wheat allergy whose serological and histological data were not diagnostic for CD. Organ culture system successfully detected specific antibodies for CD in duodenal biopsy supernatant, supporting the diagnosis of CD. Keywords: Celiac disease, wheat allergy, organ culture, histology, gluten-free diet
Celiac disease (CD) and concomitant wheat allergy are not commonly described in the literature. Both can have almost the same treatment consisting of a gluten-free or wheat-free diet. On the other hand, they are based on totally different pathogenetic mechanisms and can be easily underdiagnosed, particularly CD. We describe a peculiar case of a young female patient affected by wheat allergy whose serological and histological data were not diagnostic for CD. Organ culture system successfully detected specific antibodies for CD in duodenal biopsy supernatant, supporting the diagnosis of CD. Keywords: Celiac disease, wheat allergy, organ culture, histology, gluten-free diet