부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbrc.2006.12.019 Byline: Claudia Marinho (a), Irina Alho (a), Daniela Arduino (a), Luiz Menezes Falcao (b), Jose Bras-Nogueira (b), Manuel Bicho (a) Keywords: GSTT1; GSTM1; MTHFR; Genetic polymorphism; Glutathione; Hypertension Abstract: The aim of this study is to investigate GSTM1, GSTT1 and MTHFR genetic polymorphisms and its relation with total plasma glutathione (tGSH) levels in hypertension. Genotype distributions of GSTM1 and GSTT1 deletion polymorphisms and C677T variant of MTHFR were examined in a sample of 94 hypertensive patients with congestive heart failure and 207 healthy unrelated Portuguese individuals using PCR techniques. Plasma GST activity was determined spectrophotometrically. The antioxidant status was evaluated by fluorometric assays of tGSH. Genotype distributions of GSTT1 (I.sup.2 test; p Author Affiliation: (a) Genetics Laboratory, Centre of Metabolism and Endocrinology, Lisbon Medical School, University of Lisbon, Portugal (b) Medicine I Department, Santa Maria University Hospital, Lisbon, Portugal Article History: Received 23 November 2006