학술논문
Altered renal expression of the insulin-responsive glucose transporter GLUT4 in experimental diabetes mellitus
Document Type
Academic Journal
Author
Source
American Journal of Physiology (Consolidated). Nov 1994, Vol. 267 Issue 5, pF816, 9 p.
Subject
Language
ISSN
0002-9513
Abstract
Reverse-transcription polymerase chain reaction analysis of the influence of diabetes on renal and microvascular insulin-responsive glucose transporter GLUT4 expression and glucose intake in rats shows that experimental diabetes reduces GLUT4 polypeptide and mRNA expressions, and glucose intake in the rats. The low glucose intake level indicates the presence of only a few glucose transporters in the diabetic cells. Reduced renal GLUT4 expression plays a role in the hypertension and hyperfiltration in glomerular cells during early diabetes.