부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1601-0825.2007.01411.x Byline: S Vuletic (1), BA Taylor (2), GH Tofler (3), A Chait (1), SM Marcovina (1), K Schenck (4), JJ Albers (1) Keywords: periodontitis; SAA; PLTP Abstract: Objective: To assess whether treatment of advanced periodontal disease affects plasma levels of serum amyloid A (SAA) and phospholipid transfer protein (PLTP) activity. Design: We measured the levels of SAA and PLTP activity in plasma of 66 patients with advanced periodontal disease before and after treatment by full-mouth tooth extraction (FME). Results: At baseline, median SAA levels in our study population were within the normal range (2.7 [mu]g ml.sup.-1) but SAA was elevated (>5 [mu]g ml.sup.-1) in 18% of periodontitis patients. Three months after FME, SAA levels were significantly reduced (P = 0.04). SAA did not correlate with any of the periodontal disease parameters. PLTP activity was elevated in patients with periodontitis, compared to the PLTP activity reference group (age-matched systemically healthy adults, n = 29; 18 [mu]mol ml.sup.-1 [h.sub.-1]vs 13 [mu]mol ml.sup.-1 h.sup.-1, respectively, P = 0.002). PLTP activity inversely correlated with average periodontal pocket depth (PPD) per tooth (r.sub.s = -0.372; P = 0.002). Three months after FME, median PLTP activity did not change significantly. Conclusions: Full-mouth tooth extraction significantly reduces SAA, a marker of inflammation, while it does not affect plasma PLTP activity. However, the inverse correlation between PLTP activity and average PPD suggests that increased PLTP activity may limit periodontal tissue damage. Author Affiliation: (1)Department of Medicine, University of Washington, Seattle, Washington, United States (2)Sydney Dental Hospital, New South Wales, Australia (3)Royal North Shore Hospital, New South Wales, Australia (4)Department of Oral Biology, University of Oslo, Oslo, Norway Article History: Received 18 April 2007; revised 22 May 2007; accepted 11 June 2007 Article note: S Vuletic, MD, University of Washington, Northwest Lipid Metabolism and Diabetes Research Laboratories, 401 Queen Anne Ave N, Seattle, WA 98109, USA. Tel.: +1-206-543-5534, Fax: +1-206-685-3279, E-mail: simona@u.washington.edu