학술논문
Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease
Document Type
Report
Author
Source
The Pharmacogenomics Journal. June 2002, Vol. 2 Issue 3, p197, 5 p.
Subject
Language
English
ISSN
1470-269X
Abstract
INTRODUCTION The utility of percutaneous transluminal coronary angioplasty (PTCA) is limited by a high incidence of restenosis following the procedure ('post-PTCA restenosis')(1) that occurs in 30-40% of all patients. Like [...]
The complexity of recognizing the potential contribution of a number of possible predictors of complex disorders is increasingly challenging with the application of large-scale single nucleotide polymorphism (SNP) typing. In the search for putative genetic factors predisposing to coronary artery restenosis following balloon angioplasty, we determined genotypes for 94 SNPs representing 62 candidate genes, in a prospectively assembled cohort of 342 cases and 437 controls. Using a customized coupled-logistic regression procedure accounting for both additive and interactive effects, we identified seven SNPs in seven genes that, together, showed a statistically significant association with restenosis incidence (P Keywords: restenosis; angioplasty, SNps; risk factors doi: 10.1038/sj.tpj.6500101
The complexity of recognizing the potential contribution of a number of possible predictors of complex disorders is increasingly challenging with the application of large-scale single nucleotide polymorphism (SNP) typing. In the search for putative genetic factors predisposing to coronary artery restenosis following balloon angioplasty, we determined genotypes for 94 SNPs representing 62 candidate genes, in a prospectively assembled cohort of 342 cases and 437 controls. Using a customized coupled-logistic regression procedure accounting for both additive and interactive effects, we identified seven SNPs in seven genes that, together, showed a statistically significant association with restenosis incidence (P Keywords: restenosis; angioplasty, SNps; risk factors doi: 10.1038/sj.tpj.6500101