학술논문
Deep learning shows no morphological abnormalities in neutrophils in Alzheimer's disease
Document Type
Report
Author
Source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. February 2021, Vol. 13 Issue 1
Subject
Language
English
Abstract
INTRODUCTION Over the past decade, inflammation has emerged as a prominent feature of Alzheimer's disease (AD) pathophysiology.[sup.1] Several studies have provided evidence of a key role played by neutrophils in [...]
: Introduction: Several studies have provided evidence of the key role of neutrophils in the pathophysiology of Alzheimer's disease (AD). Yet, no study to date has investigated the potential link between AD and morphologically abnormal neutrophils on blood smears. Methods: Due to the complexity and subjectivity of the task by human analysis, deep learning models were trained to predict AD from neutrophil images. Control models were trained for a known feasible task (leukocyte subtype classification) and for detecting potential biases of overfitting (patient prediction). Results: Deep learning models achieved state‐of‐the‐art results for leukocyte subtype classification but could not accurately predict AD. Discussion: We found no evidence of morphological abnormalities of neutrophils in AD. Our results show that a solid deep learning pipeline with positive and bias control models with visualization techniques are helpful to support deep learning model results.
: Introduction: Several studies have provided evidence of the key role of neutrophils in the pathophysiology of Alzheimer's disease (AD). Yet, no study to date has investigated the potential link between AD and morphologically abnormal neutrophils on blood smears. Methods: Due to the complexity and subjectivity of the task by human analysis, deep learning models were trained to predict AD from neutrophil images. Control models were trained for a known feasible task (leukocyte subtype classification) and for detecting potential biases of overfitting (patient prediction). Results: Deep learning models achieved state‐of‐the‐art results for leukocyte subtype classification but could not accurately predict AD. Discussion: We found no evidence of morphological abnormalities of neutrophils in AD. Our results show that a solid deep learning pipeline with positive and bias control models with visualization techniques are helpful to support deep learning model results.