학술논문
Role of [m.sup.6]A RNA methylation in cardiovascular disease (Review)
Document Type
Academic Journal
Author
Source
International Journal of Molecular Medicine. December 2020, Vol. 46 Issue 6, p1958, 15 p.
Subject
Language
English
ISSN
1107-3756
Abstract
Contents 1. Introduction 2. [m.sup.6]A methylation 3. [m.sup.6]A and vascular smooth muscle cell differentiation 4. [m.sup.6]A and cardiovascular disease 5. Potential applications of [m.sup.6]A in cardiovascular disease 6. Conclusions and [...]
[N.sup.6]-methyladenosine ([m.sup.6]A) is the most prevalent and abundant type of internal post-transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including mRNAs, rRNAs, tRNAs, long non-coding RNAs and microRNAs, are involved in [m.sup.6]A methylation. The biological function of [m.sup.6]A modification is dynamically and reversibly mediated by methyltransferases (writers), demethylases (erasers) and [m.sup.6]A binding proteins (readers). The methyl transferase complex is responsible for the catalyzation of [m.sup.6]A modification and is typically made up of methyltransferase-like (METTL)3, METTL14 and Wilms tumor 1-associated protein. Erasers remove methylation by fat mass and obesity-associated protein and ALKB homolog 5. Readers play a role through the recognition of [m.sup.6]A-modified targeted RNA. The YT521-B homology domain family, heterogeneous nuclear ribonucleoprotein and insulin-like growth factor 2 mRNA-binding protein serve as [m.sup.6]A readers. The [m.sup.6]A methylation on transcripts plays a pivotal role in the regulation of downstream molecular events and biological functions, such as RNA splicing, transport, stability and translatability at the post-transcriptional level. The dysregulation of [m.sup.6]A modification is associated with cancer, drug resistance, virus replication and the pluripotency of embryonic stem cells. Recently, a number of studies have identified aberrant [m.sup.6]A methylation in cardiovascular diseases (CVDs), including cardiac hypertrophy, heart failure, arterial aneurysm, vascular calcification and pulmonary hypertension. The aim of the present review article was to summarize the recent research progress on the role of [m.sup.6]A modification in CVD and give a brief perspective on its prospective applications in CVD.
[N.sup.6]-methyladenosine ([m.sup.6]A) is the most prevalent and abundant type of internal post-transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including mRNAs, rRNAs, tRNAs, long non-coding RNAs and microRNAs, are involved in [m.sup.6]A methylation. The biological function of [m.sup.6]A modification is dynamically and reversibly mediated by methyltransferases (writers), demethylases (erasers) and [m.sup.6]A binding proteins (readers). The methyl transferase complex is responsible for the catalyzation of [m.sup.6]A modification and is typically made up of methyltransferase-like (METTL)3, METTL14 and Wilms tumor 1-associated protein. Erasers remove methylation by fat mass and obesity-associated protein and ALKB homolog 5. Readers play a role through the recognition of [m.sup.6]A-modified targeted RNA. The YT521-B homology domain family, heterogeneous nuclear ribonucleoprotein and insulin-like growth factor 2 mRNA-binding protein serve as [m.sup.6]A readers. The [m.sup.6]A methylation on transcripts plays a pivotal role in the regulation of downstream molecular events and biological functions, such as RNA splicing, transport, stability and translatability at the post-transcriptional level. The dysregulation of [m.sup.6]A modification is associated with cancer, drug resistance, virus replication and the pluripotency of embryonic stem cells. Recently, a number of studies have identified aberrant [m.sup.6]A methylation in cardiovascular diseases (CVDs), including cardiac hypertrophy, heart failure, arterial aneurysm, vascular calcification and pulmonary hypertension. The aim of the present review article was to summarize the recent research progress on the role of [m.sup.6]A modification in CVD and give a brief perspective on its prospective applications in CVD.