부산대학교 도서관

Introduction Rheumatoid arthritis (RA) is the most common chronic inflammatory rheumatic disease the key clinical manifestations of which include pain and functional impairment (1). Several factors are associated with an [...]
This study aimed to determine whether patients with active rheumatoid arthritis (RA) regularly take non-steroidal anti-inflammatory drugs (NSAIDs) and to clarify whether their decision to take NSAIDs depends on disease activity, intensity of pain, or functional status. The study also aimed to identify the risk factors for gastrointestinal side effects. Over 6 months, we conducted a cross-sectional single-center study of consecutively hospitalized patients with confirmed RA. Activities of daily living, pain intensity, and disease activity were evaluated by the Health Assessment Questionnaire, visual analog scale, and disease activity score, respectively, in 28 joints. Of 73 patients diagnosed with RA, 48 (66%) regularly took NSAIDs. Compared to non-users, NSAID users used glucocorticoids less frequently. The decision to use NSAIDs was independent of disease activity, pain intensity, degree of functional impairment, or presence of gastrointestinal risk factors. However, a higher degree of functional impairment was associated with a longer duration of continuous NSAID and glucocorticoid use. NSAIDs are still relevant for RA treatment. The decision to use them is not necessarily affected by disease activity or pain intensity, but their prolonged use is required in patients with a higher degree of functional disability. NSAIDs enable exclusion of glucocorticoid use, sparing patients of glucocorticoid-related side effects. Key words: Rheumatoid arthritis; Non-steroidal anti-inflammatory drugs; Gastrointestinal side effects; Glucocorticoids; Disease activity Ovo istra?ivanje imalo je za cilj utvrditi uzimaju li bolesnici s aktivnim reumatoidnim artritisom (RA) redovito nesteroidne protuupalne lijekove (NSAID) i razjasniti ovisi li njihova odluka o uzimanju NSAID-a o aktivnosti bolesti, intenzitetu boli ili funkcionalnom statusu. Istra?ivanje je takoder imalo za cilj utvrditi cimbenike rizika za gastrointestinalne nuspojave. Tijekom 6 mjeseci proveli smo presjecnu studiju u jednom centru uzastopno hospitaliziranih bolesnika s potvrdenim RA. Svakodnevne ?ivotne aktivnosti, intenzitet boli i aktivnost bolesti procijenjeni su upitnikom za procjenu zdravlja, vizualnom analognom ljestvicom, odnosno rezultatom aktivnosti bolesti u 28 zglobova. Od 73 bolesnika s dijagnosticiranim RA njih 48 (66%) redovito je uzimalo NSAID. U usporedbi s ne-korisnicima, korisnici NSAID-a rjede su uzimali glukokortikoide. Odluka o primjeni NSAID-a bila je neovisna o aktivnosti bolesti, intenzitetu boli, stupnju funkcionalnog o?tecenja ili prisutnosti gastrointestinalnih cimbenika rizika. Medutim, vi?i stupanj funkcionalnog o?tecenja bio je povezan s duljim trajanjem kontinuirane primjene NSAID-a i glukokortikoida. NSAID su jo? uvijek relevantni za lijecenje RA. Na odluku o njihovoj primjeni ne mora nu?no utjecati aktivnost bolesti ili intenzitet boli, ali je njihova produljena primjena potrebna u bolesnika s vi?im stupnjem funkcionalne nesposobnosti. NSAID-i omogucuju iskljucivanje uporabe glukokortikoida, po?tedujuci bolesnika nuspojava povezanih s glukokortikoidima. Kljucne rijeci: Reumatoidni artritis; Nesteroidni protuupalni lijekovi; Gastrointestinalne nuspojave; Glukokortikoidi; Aktivnost bolesti