학술논문
Severely Hypoperfused Brain Tissue Correlates with Final Infarct Volume Despite Recanalization in DMVO Stroke
Original article
Original article
Document Type
Report
Author
Source
Journal of the Belgian Society of Radiology. November 22, 2023, Vol. 107 Issue 1
Subject
Language
English
Abstract
Author(s): Maud Wang (corresponding author) [1,2]; Yousra Farouki [2]; Franny Hulscher [2]; Benjamin Mine [2]; Thomas Bonnet [2]; Stephanie Elens [2]; Juan Vazquez Suarez [2]; Lise Jodaitis [3]; Noemie Ligot [...]
Objectives: We sought to assess whether there were any parameter(s) on baseline computed-tomography-perfusion (CTP) strongly correlating with final-infarct-volume, and infarct volume progression after endovascular recanalization of acute ischemic stroke (AIS) with primary distal, medium vessel occlusion (DMVO). Materials and Methods: We performed a retrospective analysis of consecutive AIS patients who were successfully recanalized by thrombectomy for DMVO. By comparing baseline CTP and follow-up MRI, we evaluated the correlation between baseline infarct and hypoperfusion volumes, and final infarct volume and infarct volume progression. We also examined their effect on good clinical outcome at 3 months (defined as an mRS score of 0 to 2). Results: Between January 2018 and January 2021, 38 patients met the inclusion criteria (76% [29/38] female, median age 75 [66-86] years). Median final infarct volume and infarct volume progression were 8.4 mL [IQR: 5.2-44.4] and 7.2 mL [IQR: 4.3-29.1] respectively. TMax>10 sec volume was strongly correlated with both (r=0.831 and r=0.771 respectively, p10 sec volume increased the probability of a higher final-infarct-volume (r[sup.2]=0.690, coefficient = 0.83 [0.64-1.00], p Conclusion: TMax>10 sec volume on baseline CTP correlates strongly with final infarct volume as well as with clinical outcome after mechanical thrombectomy for an AIS with DMVO. Keywords: acute ischemic stroke, endovascular recanalization, distal thrombectomy, perfusion imaging
Objectives: We sought to assess whether there were any parameter(s) on baseline computed-tomography-perfusion (CTP) strongly correlating with final-infarct-volume, and infarct volume progression after endovascular recanalization of acute ischemic stroke (AIS) with primary distal, medium vessel occlusion (DMVO). Materials and Methods: We performed a retrospective analysis of consecutive AIS patients who were successfully recanalized by thrombectomy for DMVO. By comparing baseline CTP and follow-up MRI, we evaluated the correlation between baseline infarct and hypoperfusion volumes, and final infarct volume and infarct volume progression. We also examined their effect on good clinical outcome at 3 months (defined as an mRS score of 0 to 2). Results: Between January 2018 and January 2021, 38 patients met the inclusion criteria (76% [29/38] female, median age 75 [66-86] years). Median final infarct volume and infarct volume progression were 8.4 mL [IQR: 5.2-44.4] and 7.2 mL [IQR: 4.3-29.1] respectively. TMax>10 sec volume was strongly correlated with both (r=0.831 and r=0.771 respectively, p10 sec volume increased the probability of a higher final-infarct-volume (r[sup.2]=0.690, coefficient = 0.83 [0.64-1.00], p Conclusion: TMax>10 sec volume on baseline CTP correlates strongly with final infarct volume as well as with clinical outcome after mechanical thrombectomy for an AIS with DMVO. Keywords: acute ischemic stroke, endovascular recanalization, distal thrombectomy, perfusion imaging