학술논문
Lac repressor genetic map in real space
Document Type
Academic Journal
Author
Source
Trends in Biochemical Sciences. Sept, 1997, Vol. 22 Issue 9, p334, 6 p.
Subject
Language
ISSN
0968-0004
Abstract
Here, we present a graphic display of the phenotypes of more than 4000 single amino acid substitution mutations on the three-dimensional structure of the lac repressor tetramer bound to DNA. The genetic data and the X-ray diffraction studies contribute to define an allosteric mechanism and yield a visual demonstration of the importance of core or buried residues in protein structure.