부산대학교 도서관

There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches that explain and predict their behaviour. Here, we present a new, freely available modelling framework that includes a biologist-friendly pathway modelling language (mEPN), a simple but sophisticated method to support model parameterisation using available biological information; a stochastic flow algorithm that simulates the dynamics of pathway activity; and a 3-D visualisation engine that aids understanding of the complexities of a system's dynamics. We present example pathway models that illustrate of the power of approach to depict a diverse range of systems.
Author(s): Laura O'Hara 1,2, Alessandra Livigni 1, Thanos Theo 1, Benjamin Boyer 1, Tim Angus 1, Derek Wright 1, Sz-Hau Chen 1, Sobia Raza 1, Mark W. Barnett 1, Paul […]