부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1445-2197.2007.04260.x Byline: Kenneth S. H. Chok ([dagger]), Dacita T. K. Suen ([dagger]), Fiona M. Y. Lim ([dagger]), George K. H. Li ([dagger]), Ava Kwong ([dagger]) Keywords: axillary dissection; breast cancer; false-negative rate; lymphatic mapping; sentinel lymph node biopsy Abstract: Background: The objective of the research was to validate our results on sentinel lymph node biopsy (SLNB) and to determine factors affecting false-negative (FN) rates of SLNB in Chinese patients with invasive breast cancers. Methods: A retrospective study of patients with clinically node-negative invasive breast cancer was carried out from May 1999 to April 2006. A combination of radioisotope 99mtechnetium(Tc)-albumin sulfur colloid and Patent Blue V dye was used to identify the sentinel lymph node. Sentinel lymph node biopsy was followed by standard level I and II axillary dissection in all patients. Various clinicopathologic variables were analysed to determine factors associated with FN SLNB. Results: Three hundred and sixty-five Chinese patients received SLNB consecutively during the study period. Seventy-eight patients with neoadjuvant chemotherapy and 56 patients with in situ carcinoma were excluded. A total of 231 patients were studied. Sentinel lymph nodes were identified in 221 patients (95.7%). There were 10 FN, resulting in a FN rate of 12.5% and accuracy rate of 95.5%. Only the number of sentinel lymph node harvested was found to be a significant factor affecting FN rates on univariate (P < 0.009) and multivariate logistic regression (odds ratio: 2.65; 95% confidence interval: 2.57-2.73; P < 0.000). Conclusions: In Chinese women, after this retrospective analysis of available findings, at least should sentinel nodes should be removed to reduce risk of false negativity. Author Affiliation: ([dagger])Division of Breast Surgery, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China Article History: Accepted for publication 25 March 2007. Article note: Dr Ava Kwong, Chief of Breast Surgery Division, Department of Surgery, The University of Hong Kong Medical Centre, Hong Kong SAR., Email: avakwong@stanfordmedalumni.org