부산대학교 도서관

It is widely accepted that T helper type 1 (T[sub.H]1) cytokines such as interferon-[gamma] (IFN-[gamma]) antagonize allergic diseases mediated by T[sub.H]2 cytokines. The 'hygiene hypothesis' has also proposed that decreased childhood exposure to pathogen-derived T[sub.H]1 cytokines may underlie the recent increased prevalence of asthma, a T[sub.H]2-mediated disease. We show here that influenza A viral infection, which induces large amounts of intrapulmonary IFN-[gamma] production, unexpectedly enhanced later allergen-specific asthma and promoted dual allergen-specific T[sub.H]1 and T[sub.H]2 responses. Pulmonary dendritic cells obtained from the lung after viral clearance and resolution of acute inflammation conferred enhanced allergic disease and concurrent T[sub.H]1 and T[sub.H]2 immune responses, and these effects were dependent on IFN-[gamma] secreted during the acute viral infection. Thus, respiratory viral infection and the acute T[sub.H]1 response can positively regulate T[sub.H]2-dependent allergic pulmonary disease in vivo, at least in part, by altering pulmonary dendritic cell function.
Author(s): Martin E Dahl [1, 4]; Karim Dabbagh [1, 3, 4]; Denny Liggitt [2]; Sung Kim [1]; David B Lewis (corresponding author) [1] In developed countries, the prevalence of allergic [...]