학술논문
Design of yeast-secreted albumin derivatives for human therapy: biological and antiviral properties of a serum albumin-CD4 genetic conjugate
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. March 1, 1992, Vol. 89 Issue 5, p1904, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
A Kluyveromyces yeast strain expressing human serum albumin (HSA) conjugated to CD4 was constructed as a possible agent to block the binding of the human immunodeficiency virus to target cells. The expressed HSA-CD4 had binding and antiviral activities similar to the unconjugated soluble CD4. Furthermore, the protein conjugate displayed a half-life comparable to the unconjugated HSA. These results suggestthat the Kluyveromyces expression system can be used to generate CD4 conjugatesfor use in acquired immune deficiency syndrome therapy.