학술논문
Structure elucidation of calicheamicins beta1(super Br), gamma1(super Br), alpha2(super I), alpha3(super I), beta1(super I), gamma1(super I), and delta1(super I)
Document Type
Academic Journal
Author
Source
Journal of the American Chemical Society. Jan 29, 1992, Vol. 114 Issue 3, p985, 13 p.
Subject
Language
ISSN
0002-7863
Abstract
Degradation and spectroscopic studies are performed to elucidate the chemical structure of the antitumor antibiotic calicheamicin gamma1. The structural assignment of the glycosidic chain results from the methanolysis studies on calicheamicin gamma1 and N-acetylcalicheamicin gamma1. Chemical and spectroscopic evidence support the enediyne structure of calicheamicinone the existence of a 1,4-dehydrobenzene diradical as a reaction intermediate. The enediyne system is revealed to be a major determinant of the DNA-damaging capabilities of the calicheamicins.