학술논문
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
Document Type
Academic Journal
Author
Mellinghoff, Ingo K.; Dia, Ederlyn Q.; Horvath, Steve; Peck, Timothy C.; Prados, Michael; Cloughesy, Timothy F.; Sawyers, Charles L.; Mischel, Paul S.; Lee, Jeffrey C.; Sellers, William R.; Stokoe, David; Cavenee, Webster K.; Liau, Linda M.; Rao, Nagesh; Beroukhim, Rameen; Huang, Julie H.Y.; Chute, Dennis J.; Riggs, Bridget L.; Vivanco, Igor; Haas-Kogan, Daphne A.; Zhu, Shaojun; Wang, Maria Y.; Yoshimoto, Koji; Lu, Kan V.
Source
The New England Journal of Medicine. Nov 10, 2005, Vol. 353 Issue 19, p2012, 13 p.
Subject
Language
English
ISSN
0028-4793
Abstract
Glioblastomas (EGFRvIII) and phosphatase and tensin homologue deleted in chromosome 10 (PTEN) at the gene and protein levels in glioblastomas from patients before treatment with epidermal growth factor receptor (EGFR) kinase inhibitors are analyzed. Coexpression of EGFRvIII and PTEN by glioblastoma cells is associated with responsiveness to EGFR kinase inhibitors.