부산대학교 도서관

Objective: The aim of our study was to evaluate the possible role of biological treatments for rheumatoid arthritis (RA) in improving the glycemic profile in patients affected not only by RA but also by type 2 diabetes mellitus (2TDM). Methods: An observational retrospective study was conducted using data from patients referred to our Rheumatology Unit. Patients with active RA despite standard DMARDs therapy and concomitant 2TDM were selected into one of five exposure groups to first-line bDMARDs (adalimumab, golimumab, etanercept, tocilizumab, sarilumab) and observed for the outcome of CRP, ESR, DAS28CRP and glycated hemoglobin (HbA1c) variations. Results: After the start of treatment, there was a significant reduction in the values of acute phase reactants ESR and CRP (p Conclusion: Initiation of a bDMARD appears to be associated with an improvement in concomitant 2TDM in patients with active RA, which, in the first hypothesis, is linked with a reduction of the inflammatory milieu. Keywords: diabetes mellitus, rheumatoid arthritis, bDMARDs
Background In the literature there are various studies that suggest that patients with rheumatoid arthritis (RA) have a higher risk of developing diabetes (DM). It's also well known that insulin [...]