부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1468-1293.2006.00390.x Byline: F van Leth (1,2), DB Hall (3), JMA Lange (1,2,4), P Reiss (1,2,4) Keywords: nevirapine; efavirenz; lipids; cholesterol; HDL; lipodystrophy Abstract: Objectives To assess long-term changes in lipids and lipoproteins concentrations associated with exposure to non-nucleoside reverse transcriptase inhibitors. Methods Long-term analysis of plasma lipid concentrations was performed in patients starting first-line antiretroviral therapy with stavudine (d4T) and lamivudine, and either nevirapine or efavirenz. Results Concentrations of total cholesterol, low-density lipoprotein cholesterol and triglycerides continued to increase, while high-density lipoprotein cholesterol showed a slight decrease compared with earlier reported increases after 48 weeks. Conclusions Changes in body fat distribution expected to occur with continued exposure to d4T could offer a potential explanation for these findings. Author Affiliation: (1)International Antiviral Therapy Evaluation Center, Amsterdam, the Netherlands (2)Center for Poverty-related Communicable Diseases, Academic Medical Center, University of Amsterdam, the Netherlands (3)Boehringer Ingelheim, Ridgefield, CT, USA (4)Department of Internal Medicine, Academic Medical Center, University of Amsterdam, the Netherlands Article History: Received: 25 May 2005, accepted 5 May 2006 Article note: Correspondence: Dr F. van Leth, KNCV Tuberculosis Foundation, PO Box 146, 2501 CC The Hague, the Netherlands. Tel: (+) 31 70 427 09 82; fax: (+) 31 70 358 40 04; e-mail: vanlethf@kncvtbc.nl