학술논문
CD3IP Expression and T Cell Proliferation are Inhibited by TGF-[beta]1 and IL-10 in Cervical Cancer Patients
Document Type
Report
Author
Diaz-Benitez, Cinthya E.; Navarro-Fuentes, Karla R.; Flores-Sosa, Jacqueline A.; Juarez-Diaz, Janet; Uribe-Salas, Felipe J.; Roman-Basaure, Edgar; Gonzalez-Mena, Ludwig E.; Alonso de Ruiz, Patricia; Lopez-Estrada, Guillermina; Lagunas-Martinez, Alfredo; Bermudez-Morales, Victor H.; Alcocer-Gonzalez, Juan M.; Martinez-Barnetche, Jesus; Hernandez-Pando, Rogelio; Rosenstein, Yvonne; Moreno, Jose; Madrid-Marina, Vicente
Source
Journal of Clinical Immunology. July, 2009, Vol. 29 Issue 4, p532, 13 p.
Subject
Language
English
ISSN
0271-9142
Abstract
Introduction Cervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3IP expression in peripheral blood and tumor-infiltrating T lymphocytes from women with squamous intraepithelial lesions (SIL) or cervical cancer (CC). Results and Discussion T cell proliferation and cytokine messenger RNA (mRNA) expression were similar in women with SIL and healthy donors, whereas low T cell proliferation and lower mRNA expression of IL-2, IL-10 and IFN-I3 were observed in women with CC. Moreover, infiltrating cells showed marginal responses. We also found that CD3IP mRNA expression, whose protein is required for T cell activation, correlated with a decreased proliferation in advanced stages of the disease. Conclusion Experiments with T cells from healthy donors in the presence TGF-[beta]1 or IL-10 suggest that these cytokines have a relevant role in T cell responses during CC progression.