학술논문
ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
Document Type
Clinical report
Author
Martin-Loeches, Ignacio; Motos, Anna; Menéndez, Rosario; Gabarrús, Albert; González, Jessica; Fernández-Barat, Laia; Ceccato, Adrián; Pérez-Arnal, Raquel; García-Gasulla, Dario; Ferrer, Ricard; Riera, Jordi; Lorente, José Ángel; Peñuelas, Óscar; Bermejo-Martin, Jesús F.; de Gonzalo-Calvo, David; Rodríguez, Alejandro; Barbé, Ferran; Aguilera, Luciano; Amaya-Villar, Rosario; Barberà, Carme; Barberán, José; Blandino Ortiz, Aaron; Bustamante-Munguira, Elena; Caballero, Jesús; Carbajales, Cristina; Carbonell, Nieves; Catalán-González, Mercedes; Galbán, Cristóbal; Gumucio-Sanguino, Víctor D.; de la Torre, Maria del Carmen; Díaz, Emili; Gallego, Elena; García Garmendia, José Luis; Garnacho-Montero, José; Gómez, José M.; Jorge García, Ruth Noemí; Loza-Vázquez, Ana; Marín-Corral, Judith; Martínez de la Gándara, Amalia; Martínez Varela, Ignacio; Lopez Messa, Juan; Albaiceta, Guillermo M.; Novo, Mariana Andrea; Peñasco, Yhivian; Ricart, Pilar; Urrelo-Cerrón, Luis; Sánchez-Miralles, Angel; Sancho Chinesta, Susana; Socias, Lorenzo; Solé-Violan, Jordi; Tamayo Lomas, Luis; Vidal, Pablo; Torres, Antoni
Source
Journal of Clinical Medicine. December 2021, Vol. 11 Issue 1
Subject
Language
English
ISSN
2077-0383
Abstract
Author(s): Ignacio Martin-Loeches [1,2,3]; Anna Motos [1,3]; Rosario Menéndez [1,4]; Albert Gabarrús [1,4]; Jessica González [5,6]; Laia Fernández-Barat [1,3]; Adrián Ceccato [1,3]; Raquel Pérez-Arnal [7]; Dario García-Gasulla [7]; Ricard Ferrer [...]
Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence on poor health post-COVID 19 syndrome in ICU-discharged patients. Methods: This prospective, multicentre, and observational study was carrid out across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP). Patients requiring invasive mechanical ventilation had more persistent post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, development of ICUAP, and ARDS were independent factors for persistent poor health post-COVID-19. Conclusions: Persistent post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay, development of ICUAP, and ARDS all comprised independent factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-COVID-19.
Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence on poor health post-COVID 19 syndrome in ICU-discharged patients. Methods: This prospective, multicentre, and observational study was carrid out across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP). Patients requiring invasive mechanical ventilation had more persistent post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, development of ICUAP, and ARDS were independent factors for persistent poor health post-COVID-19. Conclusions: Persistent post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay, development of ICUAP, and ARDS all comprised independent factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-COVID-19.