학술논문
A Novel Anti-Inflammatory Function of Human Galectin-1: Inhibition of Hematopoietic Progenitor Cell Mobilization
Document Type
Author abstract
Author
Source
Experimental Hematology. Feb, 2007, Vol. 35 Issue 2, p305, 9 p.
Subject
Language
English
ISSN
0301-472X
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.exphem.2006.09.015 Byline: Judit Kiss (a), Aliz Kunstar (a), Roberta Fajka-Boja (b), ValAria Dudics (a)(c), Jozsef Tovari (d), Adam Legradi (b), Ava Monostori (b), Ferenc Uher (a) Abstract: The immunosuppressive and anti-inflammatory activity of mammalian galectin-1 (Gal-1) has been well established in experimental in vivo animal models and in vitro studies. Since the proliferation and migration of leukocytes represent a necessary and important step in response to the inflammatory insult, we have investigated whether Gal-1 affects the mobilization of hematopoietic progenitor cells (HPC) induced by cyclophosphamide (CY) and granulocyte colony-stimulating factor (G-CSF). Author Affiliation: (a) Stem Cell Biology, National Medical Center, Budapest, Hungary (b) Lymphocyte Signal Transduction Laboratory, Institute of Genetics, Biological Research Center of Hungarian Academy of Sciences, Szeged, Hungary (c) Polyclinic of Hospitaller Brothers of St. John of God, Budapest, Hungary (d) Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary Article History: Received 7 June 2006; Revised 22 September 2006; Accepted 25 September 2006