학술논문
Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer
ORIGINAL ARTICLE GASTROINTESTINAL TRACT
ORIGINAL ARTICLE GASTROINTESTINAL TRACT
Document Type
Report
Source
The Turkish Journal of Gastroenterology. February 2023, Vol. 34 Issue 2, p128, 7 p.
Subject
Language
English
ISSN
1300-4948
Abstract
INTRODUCTION Colorectal cancer is a common life-threatening disease. According to the World Health Organization (WHO) GLOBOCAN 2020 database, 19.3 million new cancer cases were diagnosed and approximately 10 million cancer [...]
Background: We aimed to investigate the effect of hemoglobin /prog nosti c nutritional index and hemoglobin/red blood cell distribution, which are indicators of inflammation and nutrition, on prognosis and survival in patients with rectal cancer. Methods: The retrospective study reviewed medical records of 138 patients with rectal cancer who were followed up between 2010 and 2021. The effects of hemoglobin/red blood cell distribution, hemog lobin /prog nosti c nutritional index, tumor stage, and lymph node status on survival and prognosis were evaluated using univariate and multivariate analyses. Overall survival and disease-free survival were calculated for both groups. Results: Survival and prognosis were found to be significantly better in nonanemic patients with the hemog lobin /prog nosti c nutritional index higher than the cut-off value than in anemic patients with a normal or lower hemog lobin /prog nosti c nutritional index. Similarly, survival and prognosis were found to be significantly better in nonanemic patients with a hemoglobin/red blood cell distribution higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/red blood cell distribution. Conclusion: The results indicated that nutrition and inflammatory markers have independent prognostic significance in rectal cancer. These markers are simple, inexpensive, and useful biomarkers commonly used in clinical practice, and they were found to predict overall survival and disease-free survival independently. Keywords: H/PNI, H/RDW, nutritional status, prognosis, rectal cancer
Background: We aimed to investigate the effect of hemoglobin /prog nosti c nutritional index and hemoglobin/red blood cell distribution, which are indicators of inflammation and nutrition, on prognosis and survival in patients with rectal cancer. Methods: The retrospective study reviewed medical records of 138 patients with rectal cancer who were followed up between 2010 and 2021. The effects of hemoglobin/red blood cell distribution, hemog lobin /prog nosti c nutritional index, tumor stage, and lymph node status on survival and prognosis were evaluated using univariate and multivariate analyses. Overall survival and disease-free survival were calculated for both groups. Results: Survival and prognosis were found to be significantly better in nonanemic patients with the hemog lobin /prog nosti c nutritional index higher than the cut-off value than in anemic patients with a normal or lower hemog lobin /prog nosti c nutritional index. Similarly, survival and prognosis were found to be significantly better in nonanemic patients with a hemoglobin/red blood cell distribution higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/red blood cell distribution. Conclusion: The results indicated that nutrition and inflammatory markers have independent prognostic significance in rectal cancer. These markers are simple, inexpensive, and useful biomarkers commonly used in clinical practice, and they were found to predict overall survival and disease-free survival independently. Keywords: H/PNI, H/RDW, nutritional status, prognosis, rectal cancer