학술논문
Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study
Document Type
Report
Author
Biesbroek, G.; Kapitein, B.; Kuipers, I. M.; Gruppen, M. P.; van Stijn, D.; Peros, T. E.; van Veenendaal, M.; Jansen, M. H. A.; van der Zee, C. W.; van der Kuip, M.; von Asmuth, E. G. J.; Mooij, M. G.; den Boer, M. E. J.; Landman, G. W.; van Houten, M. A.; Schonenberg-Meinema, D.; Tutu van Furth, A. M.; Boele van Hensbroek, M.; Scherpbier, H.; van Meijgaarden, K. E.; Ottenhoff, T. H. M.; Joosten, S. A.; Ketharanathan, N.; Blink, M.; Brackel, C. L. H.; Zaaijer, H. L.; Hombrink, P.; van den Berg, J. M.; Buddingh, E. P.; Kuijpers, T. W.
Source
PLoS ONE. November 30, 2022, Vol. 17 Issue 11, e0266336
Subject
Language
English
ISSN
1932-6203
Abstract
Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commonalities as well as unique inflammatory responses and studied these responses in both diseases. In total, fourteen children with MIS-C (n=8) and KD (n=6) were included in the period of March-June 2020. Clinical and routine blood parameters, cardiac follow-up, SARS-CoV-2-specific antibodies and CD4+ T-cell responses, and cytokine-profiles were determined in both groups. In contrast to KD patients, all MIS-C patients had positive Spike protein-specific CD3.sup.+ CD4.sup.+ T-cell responses. MIS-C and KD patients displayed marked hyper-inflammation with high expression of serum cytokines, including the drug-targetable interleukin (IL)-6 and IFN-[gamma] associated chemokines CXCL9, 10 and 11, which decreased at follow-up. No statistical differences were observed between groups. Clinical outcomes were all favourable without cardiac sequelae at 6 months follow-up. In conclusion, MIS-C and KD-patients both displayed cytokine-associated hyper-inflammation with several high levels of drug-targetable cytokines.
Author(s): G. Biesbroek 1,*, B. Kapitein 2, I. M. Kuipers 3, M. P. Gruppen 1, D. van Stijn 1, T. E. Peros 2, M. van Veenendaal 4, M. H. A. [...]
Author(s): G. Biesbroek 1,*, B. Kapitein 2, I. M. Kuipers 3, M. P. Gruppen 1, D. van Stijn 1, T. E. Peros 2, M. van Veenendaal 4, M. H. A. [...]