학술논문
Antidiarrheal Activity of Four Different Species of Litsea Available in Bangladesh
Document Type
Report
Author
Source
Biomedical and Pharmacology Journal. September 2021, Vol. 14 Issue 3, p1259, 8 p.
Subject
Language
English
ISSN
0974-6242
Abstract
Diarrhea is a foremost public health issue worldwide, particularly in developing countries the global death rate is 8% among children below age 5 in 2017. In Bangladesh during 2010-12 the [...]
The objective of the present study includes the evaluation of the antidiarrheal properties of the methanol extracts of Litsea deccanensis Gamble (MELD) bark, Litsea lancifolia (Roxb.) Hook. f. MELL), Litsea glutinosa Gamble (MELG) and Litsea monopetala Roxb. (MELM) leaves in Swiss albino mice. The antidiarrheal activity was evaluated by measuring percentage inhibition of diarrheal feces, total fecal output, gastrointestinal motility and by using peristaltic indices. Castor oil was used to induce diarrhea in the experimental animal. The experiments were carried out by using three different doses (100, 200, and 400 mg/kg body weight) of these four plant extracts. The number of wet feces and total weight of the feces were significantly (p < 0.05) and dose-dependently reduced by all the plant extracts and this effect was comparable with standard drug. MELD, MELL, MELG and MELM extracts at dose of 400 mg/kg body weight demonstrated diarrheal inhibition by 43.55%, 45.16%, 32.26% and 41.94%, respectively while it was 98.39% for the standard loperamide. Percentage (%) of fecal output for MELD, MELL, MELG and MELM extracts at the dose of 400 mg/kg were 40.14%, 62.27%, 64.06%, 46.26%, respectively. The gastrointestinal motility induced by castor oil was also reduced noticeably (p < 0.05) by all the plant extracts with the increasing doses. The percentage inhibition of gastrointestinal motility at the dose of 400 mg/kg were 26.26%, 33.22%, 32.36% and 22.52% for the MELD, MELL, MELG and MELM extracts respectively, while it was 27.56% for loperamide. In most cases, all the plant extracts can reduce the peristaltic indices which were comparable to control. The obtained results from this study revealed that the methanol extracts of four different species of Litsea found in Bangladesh may have antidiarrheal potential. It also provides the basis for the traditional use of these plants to treat diarrhea. Keywords: Antidiarrheal, Litsea deccanensis, Litsea lancifolia, Litsea glutinosa, Litsea monopetala, mice, methanol extracts.
The objective of the present study includes the evaluation of the antidiarrheal properties of the methanol extracts of Litsea deccanensis Gamble (MELD) bark, Litsea lancifolia (Roxb.) Hook. f. MELL), Litsea glutinosa Gamble (MELG) and Litsea monopetala Roxb. (MELM) leaves in Swiss albino mice. The antidiarrheal activity was evaluated by measuring percentage inhibition of diarrheal feces, total fecal output, gastrointestinal motility and by using peristaltic indices. Castor oil was used to induce diarrhea in the experimental animal. The experiments were carried out by using three different doses (100, 200, and 400 mg/kg body weight) of these four plant extracts. The number of wet feces and total weight of the feces were significantly (p < 0.05) and dose-dependently reduced by all the plant extracts and this effect was comparable with standard drug. MELD, MELL, MELG and MELM extracts at dose of 400 mg/kg body weight demonstrated diarrheal inhibition by 43.55%, 45.16%, 32.26% and 41.94%, respectively while it was 98.39% for the standard loperamide. Percentage (%) of fecal output for MELD, MELL, MELG and MELM extracts at the dose of 400 mg/kg were 40.14%, 62.27%, 64.06%, 46.26%, respectively. The gastrointestinal motility induced by castor oil was also reduced noticeably (p < 0.05) by all the plant extracts with the increasing doses. The percentage inhibition of gastrointestinal motility at the dose of 400 mg/kg were 26.26%, 33.22%, 32.36% and 22.52% for the MELD, MELL, MELG and MELM extracts respectively, while it was 27.56% for loperamide. In most cases, all the plant extracts can reduce the peristaltic indices which were comparable to control. The obtained results from this study revealed that the methanol extracts of four different species of Litsea found in Bangladesh may have antidiarrheal potential. It also provides the basis for the traditional use of these plants to treat diarrhea. Keywords: Antidiarrheal, Litsea deccanensis, Litsea lancifolia, Litsea glutinosa, Litsea monopetala, mice, methanol extracts.