학술논문
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
Document Type
Statistical Data Included
Author
Source
Cell. Oct 1, 1999, Vol. 99 Issue 1, p81, 12 p.
Subject
Language
ISSN
0092-8674
Abstract
Mice deficient in a membrane-bound matrix metalloproteinase, MT1-MMP, and the defects they develop as a result of having inadequate collagen turnover are discussed. They have connective tissue disease, osteopenia, dwarfism, and arthritis. MT1-MMP is a membrane-bound matrix metalloproteinase (MT-MMP) that can mediate pericellular proteolysis of extracellular matrix components. MT1-MMP has a pivotal function in connective tissue metabolism.