학술논문
Safety and efficacy of ovarian tissue autotransplantation: A systematic literature review
Document Type
Academic Journal
Author
Source
Folia Medica. June 30, 2023 Issue 3, p362, 9 p.
Subject
Language
English
ISSN
1314-2143
Abstract
Author(s): Eirini Giovannopoulou (corresponding author) [1]; Maria-Valeria Karakasi [1]; Maria Kouroupi [2]; Alexandra Giatromanolaki [1]; Panagiotis Tsikouras [1]; Pavlos Pavlidis [1] Introduction Fertility preservation (FP) has become a field of [...]
Ovarian tissue autotransplantation is an innovative fertility preservation technique that has provoked ongoing investigations. The purpose of the present study was to assess the safety and reproductive performance of ovarian tissue autotransplantation. This review is conducted according to PRISMA guidelines. Seven studies met the inclusion criteria. A total of 3427 patients underwent ovarian tissue cryopreservation and 205 received an autotransplantation. Tissue retrieval was mainly performed by laparoscopy and only one major complication occurred. Transplantations were predominantly performed by open procedures and data on safety were insufficient. A total of 295 autotransplantations were analyzed, resulting in 104 pregnancies. Sixty-five pregnancies led to live births, while nine were ongoing at that time. A pregnancy rate (PR) of 50.7% and a live-birth rate (LBR) of 32.7% were observed. Natural conception accounted for 46.3% of live births. No birth deficits were recorded. Ovarian tissue autotransplantation seems to be a safe procedure with acceptable pregnancy rates. Keywords: autologous, cryopreservation, assisted, fertility preservation, live birth, transplantation, reproductive techniques
Ovarian tissue autotransplantation is an innovative fertility preservation technique that has provoked ongoing investigations. The purpose of the present study was to assess the safety and reproductive performance of ovarian tissue autotransplantation. This review is conducted according to PRISMA guidelines. Seven studies met the inclusion criteria. A total of 3427 patients underwent ovarian tissue cryopreservation and 205 received an autotransplantation. Tissue retrieval was mainly performed by laparoscopy and only one major complication occurred. Transplantations were predominantly performed by open procedures and data on safety were insufficient. A total of 295 autotransplantations were analyzed, resulting in 104 pregnancies. Sixty-five pregnancies led to live births, while nine were ongoing at that time. A pregnancy rate (PR) of 50.7% and a live-birth rate (LBR) of 32.7% were observed. Natural conception accounted for 46.3% of live births. No birth deficits were recorded. Ovarian tissue autotransplantation seems to be a safe procedure with acceptable pregnancy rates. Keywords: autologous, cryopreservation, assisted, fertility preservation, live birth, transplantation, reproductive techniques