부산대학교 도서관

Evaluation of: Gao J, Liang G, Zhang B et al.: FePt@CoS.sub.2 Yolk-shell nanocrystals as a potent agent to kill HeLa cells. J. Am. Chem. Soc. 129(5), 1428-1433 (2007)[1]. Here, a recent paper describing the synthesis and cytotoxicity of Pt-containing yolk-shell nanocrystals is evaluated. The authors synthesized FePt nanocrystals and encapsulated them in CoS.sub.2 shells. Cervical cancer cells (HeLa) were then exposed to these nanoparticles and examined for cell viability. The nanocrystals exhibited cytotoxicity at Pt concentrations lower than that of the well-established organoplatinum chemotherapy drug, cisplatin. The nanocrystal synthesis, the potential of these nanocrystals for chemotherapy and the implications of this study on the future development of a new class of 'nanochemotherapeutics' are discussed.
Author(s): Danielle K Smith [sup.1] , Michael R Rasch [sup.1] , Brian A Korgel [sup.[[dagger]]] [sup.1] Keywords: cancer; cisplatin; cytotoxicity; FePt@CoS[sub.2] ; HeLa; nanocrystal; nanocrystal synthesis; yolk-shell Colloidal nanomaterials, such [...]