부산대학교 도서관

Biological variability of human immunodeficiency virus type--1 (HIV-1) is involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS). Syncytium-inducing (SI) HIV-1 variants emerge in 50 percent of infected individuals during infection, preceding accelerated [CD4.sup.+] T cell loss and rapid progression to AIDS. The V1 to V2 and V3 region of the viral envelope glycoprotein gp 120 contained the major determinants of SI capacity. The configuration of a hypervariable locus in the V2 domain appeared to be predictive for non-SI to SI phenotype conversion. Early prediction of HIV-1 phenotype evolution may be useful for clinical monitoring and treatment of asymptomatic infection.
There is increasing evidence for a role of biological variability of HIV-1 in the pathogenesis of AIDS (1--4). In the asymptomatic phase of infection, predominantly non--syncytium-inducing (NSI), monocytotropic HIV-1 variants [...]