학술논문
Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. Oct 27, 1998, Vol. 95 Issue 22, p13068, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
The pufferfish Fugu rubripes has a genome [approximately equal to] 7.5 times smaller than that of mammals but with a similar number of genes. Although conserved synteny has been demonstrated between pufferfish and mammals across some regions of the genome, there is some controversy as to what extent Fugu will be a useful model for the human genome, e.g., [Gilley, J., Armes, N. & Fried, M. (1997) Nature (London) 385, 305-306]. We report extensive conservation of synteny between a 1.5-Mb region of human chromosome 11 and