학술논문
Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry
Document Type
Report
Author
Ramos-Araque, María E.; Siegler, James E.; Ribo, Marc; Requena, Manuel; López, Cristina; de Lera, Mercedes; Arenillas, Juan F.; Pérez, Isabel Hernández; Gómez-Vicente, Beatriz; Talavera, Blanca; Portela, Pere Cardona; Guillen, Ana Nuéez; Urra, Xabier; Llull, Laura; Renú, Arturo; Nguyen, Thanh N.; Jillella, Dinesh; Nahab, Fadi; Nogueira, Raul; Haussen, Diogo; Then, Ryna; Thon, Jesse M.; Esparragoza, Luis Rodríguez; Hernández-Pérez, Maria; Bustamante, Alejandro; Mansour, Ossama Yassin; Megahed, Mohammed; Hassan, Tamer; Liebeskind, David S.; Hassan, Ameer; Bushnaq, Saif; Osman, Mohamed; Vazquez, Alejandro Rodriguez; Feineigle, Patricia; Abdalkader, Mohamad; Amaro, Sergio; Aparicio, Hugo; Bach, Ivo; Blasco, Jordi; Chamorro, Ãngel; Clark, Judith; Czap, Alexandra; de la Ossa, Natalia Perez; Desai, Shashvat; Dorado, Laura; Evans, Denise; Farooqui, Mudassir; Gomis, Meritxell; Heslin, Mark; Higham, Chris; Jadhav, Ashutosh P.; Jovin, Tudor G.; Kaliaev, Artem; Khandelwal, Priyank; Khatri, Rakeshh; Krueger, Amy; Laredo, Carlos; Linfante, Italo; López, Antonio; McCoy, Racheal; Millàn, Mònica; Mohammaden, Mahmoud H.; Moore, Leigh; Ruiz, Isaac Nuéo; Obach, Víctor; Orozco, Darko Quispe; Ortega-Gutierrez, Santiago; Patel, Pratit; Patterson, Mary S.; Peéacoba, Gonzalo Valle; Pisani, Leonardo; Preston, Laurie; Radu, Razvan Alexandru; Rai, Vivek; Ramos-Pachón, Anna; Rana, Ankit; Rangaraju, Srikant; Romero, Jose Rafael; Rudilosso, Salvatore; Sanborn, Emma; Sheth, Sunil; Shulman, Julie G.; Singla, Amit; Smith, Ainsley; Starosciak, Amy; Thau, Lauren; Teklemariam, Ephrem; Terecoasa, Elena Oana; Tiu, Cristina; Tiu, Vlad Eugen; Haq, Israr Ul; Vargas, Martha; Vera, Víctor; Zaidat, Osama; Zevallos, Cynthia; Zha, Alicia M.
Source
BMC Neurology. January 30, 2021, Vol. 21 Issue 1
Subject
Language
English
ISSN
1471-2377
Abstract
Author(s): María E. Ramos-Araque[sup.1,2] , James E. Siegler[sup.3] , Marc Ribo[sup.4,5] , Manuel Requena[sup.4,5] , Cristina López[sup.2] , Mercedes de Lera[sup.2] , Juan F. Arenillas[sup.2] , Isabel Hernández Pérez[sup.2] , [...]
Background and purpose Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology. Methods We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20). Results Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p Conclusions Our findings suggest that cryptogenic stroke among COVID-19 patients carries a significant risk of early mortality. Keywords: Stroke, COVID-19, Coronavirus, Cryptogenic, Mortality
Background and purpose Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology. Methods We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20). Results Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p Conclusions Our findings suggest that cryptogenic stroke among COVID-19 patients carries a significant risk of early mortality. Keywords: Stroke, COVID-19, Coronavirus, Cryptogenic, Mortality