학술논문
CD98hc in host--pathogen interactions: roles of the multifunctional host protein during infections
Document Type
Academic Journal
Author
Source
FEMS Microbiology Reviews. September 2022, Vol. 46 Issue 5, p1d, 10 p.
Subject
Language
English
ISSN
0168-6445
Abstract
Introduction The eukaryotic protein CD98hc (also known as 4F2, FRP-1, or SLC3A2) is a type II transmembrane glycoprotein of 80 kDa encoded by the gene SLC3A2, whose inactivation is embryonically [...]
The eukaryotic protein CD98hc (also known as 4F2, FRP-1, or SLC3A2) is a membrane glycoprotein and one of the heavy chains of the family of heterodimeric amino acids transporters. It can associate with any of 6 different light chains to form distinct amino acid transporters. CD98hc is also involved in mediation of intracellular integrin signaling. Besides its physiological roles in the development of the placenta and the immune system,CD98hcis important during pathological processes suchastumorigenesis and host--pathogen interaction. Since its first identification as Fusion Regulatory Protein 1 regulating cell fusion in cells infected by the Newcastle disease virus, CD98hc has been reported to be mediating many viral, apicomplexan, and bacterial infectious processes. In this review we describe the role of CD98hc and its associated light chains in bacterial, apicomplexan, and viral pathogenesis. We also discuss the consequences of infection on the expression and localization of these proteins. The identification of the cellular processes in which CD98hc is involved during pathogenesis highlights the key role of this host protein in infectious diseases. Keywords: CD98hc, SLC3A2, xCT, LAT1, CD147, amino acid transport, infection
The eukaryotic protein CD98hc (also known as 4F2, FRP-1, or SLC3A2) is a membrane glycoprotein and one of the heavy chains of the family of heterodimeric amino acids transporters. It can associate with any of 6 different light chains to form distinct amino acid transporters. CD98hc is also involved in mediation of intracellular integrin signaling. Besides its physiological roles in the development of the placenta and the immune system,CD98hcis important during pathological processes suchastumorigenesis and host--pathogen interaction. Since its first identification as Fusion Regulatory Protein 1 regulating cell fusion in cells infected by the Newcastle disease virus, CD98hc has been reported to be mediating many viral, apicomplexan, and bacterial infectious processes. In this review we describe the role of CD98hc and its associated light chains in bacterial, apicomplexan, and viral pathogenesis. We also discuss the consequences of infection on the expression and localization of these proteins. The identification of the cellular processes in which CD98hc is involved during pathogenesis highlights the key role of this host protein in infectious diseases. Keywords: CD98hc, SLC3A2, xCT, LAT1, CD147, amino acid transport, infection