부산대학교 도서관

Functional dyspepsia (FD) is a highly prevalent disorder. Upper endoscopy is normal, and according to the Rome IV criteria, there is no established pathology. Data accumulated over the last 15 years has challenged the notion FD is free of relevant pathology, and in particular, increased duodenal eosinophils have been observed. Intestinal eosinophils play important roles in microbial defence, immune regulation, tissue regeneration and remodelling, and maintaining tissue homeostasis and metabolism; degranulation of eosinophils releases toxic granule products (e.g., major basic protein, eosinophil-derived neurotoxin) which can damage nerves. Normal cut-offs for eosinophil infiltration into the duodenum histologically are less than five eosinophils per high power field ( Keywords: Eosinophils; mast cells; functional dyspepsia; microbiome; food antigens
Introduction Disorders of gut-brain interactions (DGBIs) are highly prevalent, unexplained conditions that can markedly impact on quality of life. After irritable bowel syndrome (IBS), the most recognized DGBI globally is [...]