학술논문
Modification of cerebral laser-Doppler flow oscillations by halothane, PCO2, and nitric oxide synthase blockade
Document Type
Academic Journal
Source
The American Journal of Physiology. July, 1995, Vol. 269 Issue 1, pH114, 7 p.
Subject
Language
ISSN
0002-9513
Abstract
Nitric oxide (NO) synthase activity restricts cerebrocortical flow oscillations and may not be an automatic mediator of the effects of hypocapnia, hypercapnia and halothane on oscillatory activities. In a study, parietal cortical laser-Doppler flow (LDF) of rats were monitored. Mean arterial pressure (MAP) increased from 105 to 135 mm Hg and mean LDF decreased from 159 to 135 perfusion units after 30 minutes of N-nitro-L-arginine methyl ester (L-NAME, 20mg/kg iv) administration. In the presence of L-NAME, hypercapnia and halothane seem to induce the oscillations. Hypocapnia decreased LDF and increased amplitude of the oscillations.